BDBM50264078 9-cyclohexyl-2-hydroxy-6,11-dihydro-5H-benzo[a]carbazole-3-carboxylic acid::CHEMBL489366

SMILES: OC(=O)c1cc2CCc3c([nH]c4cc(ccc34)C3CCCCC3)-c2cc1O

InChI Key: InChIKey=ATWVRTSGPNMRHC-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50264078   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Thrombopoietin receptor (Homo sapiens (Human))	BDBM50264078 (9-cyclohexyl-2-hydroxy-6,11-dihydro-5H-benzo[a]car...) Show SMILES OC(=O)c1cc2CCc3c([nH]c4cc(ccc34)C3CCCCC3)-c2cc1O Show InChI InChI=1S/C23H23NO3/c25-21-12-18-15(10-19(21)23(26)27)7-9-17-16-8-6-14(11-20(16)24-22(17)18)13-4-2-1-3-5-13/h6,8,10-13,24-25H,1-5,7,9H2,(H,26,27)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL					Assay Description Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression				Bioorg Med Chem Lett 18: 5255-8 (2008) Article DOI: 10.1016/j.bmcl.2008.08.068 BindingDB Entry DOI: 10.7270/Q2HH6M05
					More data for this Ligand-Target Pair