BDBM50264729 CHEMBL4101882

SMILES: CNc1nccc(n1)C1(CC1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(Cl)c(c1)C(F)(F)F

InChI Key: InChIKey=OUNQRCDSRRWMKW-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50264729   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50264729 (CHEMBL4101882) Show SMILES CNc1nccc(n1)C1(CC1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(Cl)c(c1)C(F)(F)F Show InChI InChI=1S/C24H21ClF3N5O2/c1-13-3-4-14(20(34)31-15-5-6-17(25)16(12-15)24(26,27)28)11-18(13)32-21(35)23(8-9-23)19-7-10-30-22(29-2)33-19/h3-7,10-12H,8-9H2,1-2H3,(H,31,34)(H,32,35)(H,29,30,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of CRAF (unknown origin) using human His6-tagged MEK1 K97R mutant as substrate pretreated for 20 mins followed by [33P]-ATP addition measu...				Eur J Med Chem 130: 86-106 (2017) Article DOI: 10.1016/j.ejmech.2017.02.041 BindingDB Entry DOI: 10.7270/Q2DN47JG
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50264729 (CHEMBL4101882) Show SMILES CNc1nccc(n1)C1(CC1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(Cl)c(c1)C(F)(F)F Show InChI InChI=1S/C24H21ClF3N5O2/c1-13-3-4-14(20(34)31-15-5-6-17(25)16(12-15)24(26,27)28)11-18(13)32-21(35)23(8-9-23)19-7-10-30-22(29-2)33-19/h3-7,10-12H,8-9H2,1-2H3,(H,31,34)(H,32,35)(H,29,30,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	287	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of wild-type BRAF (unknown origin) using human His6-tagged MEK1 K97R mutant as substrate pretreated for 20 mins followed by [33P]-ATP addi...				Eur J Med Chem 130: 86-106 (2017) Article DOI: 10.1016/j.ejmech.2017.02.041 BindingDB Entry DOI: 10.7270/Q2DN47JG
					More data for this Ligand-Target Pair
RAF serine/threonine protein kinase (Homo sapiens (Human))	BDBM50264729 (CHEMBL4101882) Show SMILES CNc1nccc(n1)C1(CC1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(Cl)c(c1)C(F)(F)F Show InChI InChI=1S/C24H21ClF3N5O2/c1-13-3-4-14(20(34)31-15-5-6-17(25)16(12-15)24(26,27)28)11-18(13)32-21(35)23(8-9-23)19-7-10-30-22(29-2)33-19/h3-7,10-12H,8-9H2,1-2H3,(H,31,34)(H,32,35)(H,29,30,33)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	194	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of ARAF (unknown origin) using human His6-tagged MEK1 K97R mutant as substrate pretreated for 20 mins followed by [33P]-ATP addition measu...				Eur J Med Chem 130: 86-106 (2017) Article DOI: 10.1016/j.ejmech.2017.02.041 BindingDB Entry DOI: 10.7270/Q2DN47JG
					More data for this Ligand-Target Pair