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BDBM50265041 CHEMBL525804::N-(4-(6-(2-(1-(pyridin-2-yl)ethylamino)-4-(trifluoromethyl)phenyl)pyrimidin-4-yloxy)benzo[d]thiazol-2-yl)acetamide

SMILES: CC(Nc1cc(ccc1-c1cc(Oc2cccc3sc(NC(C)=O)nc23)ncn1)C(F)(F)F)c1ccccn1

InChI Key: InChIKey=QXLMKVMKRUKAFT-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50265041   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Vanilloid receptor


(Rattus norvegicus (rat))		BDBM50265041
PNG
(CHEMBL525804 | N-(4-(6-(2-(1-(pyridin-2-yl)ethylam...)
Show SMILES CC(Nc1cc(ccc1-c1cc(Oc2cccc3sc(NC(C)=O)nc23)ncn1)C(F)(F)F)c1ccccn1
Show InChI InChI=1S/C27H21F3N6O2S/c1-15(19-6-3-4-11-31-19)34-21-12-17(27(28,29)30)9-10-18(21)20-13-24(33-14-32-20)38-22-7-5-8-23-25(22)36-26(39-23)35-16(2)37/h3-15,34H,1-2H3,(H,35,36,37)
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Article
PubMed
n/an/a 0.480n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in CHO cells assessed as inhibition of capsaicin-induced 45Ca2+ influx by FLIPR assay

Bioorg Med Chem Lett 18: 5118-22 (2008)


Article DOI: 10.1016/j.bmcl.2008.07.112
BindingDB Entry DOI: 10.7270/Q27D2TXQ
More data for this
Ligand-Target Pair