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BDBM50265230 3-(3-(6-(4-(2-chloro-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)benzyl)phenoxy)hexylamino)-3-oxopropyl)-5,5-difluoro-7,9-dimethyl-5H-dipyrrolo[1,2-c:1',2'-f][1,3,2]diazaborinin-4-ium-5-uide::CHEMBL504484

SMILES: Cc1cc(C)n2c1C=C1C=CC(CCC(=O)NCCCCCCOc3ccc(Cc4cc(ccc4Cl)[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)cc3)=[N+]1[B-]2(F)F

InChI Key: InChIKey=CPJYVUYFKPKRGP-RZJQWKCISA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50265230   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sodium/glucose cotransporter 2


(Homo sapiens (Human))		BDBM50265230
PNG
(3-(3-(6-(4-(2-chloro-5-((2S,3R,4R,5S,6R)-3,4,5-tri...)
Show SMILES Cc1cc(C)n2c1C=C1C=CC(CCC(=O)NCCCCCCOc3ccc(Cc4cc(ccc4Cl)[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)cc3)=[N+]1[B-]2(F)F |r,c:10,52,t:8|
Show InChI InChI=1S/C39H47BClF2N3O7/c1-24-19-25(2)45-33(24)22-30-11-10-29(46(30)40(45,42)43)12-16-35(48)44-17-5-3-4-6-18-52-31-13-7-26(8-14-31)20-28-21-27(9-15-32(28)41)39-38(51)37(50)36(49)34(23-47)53-39/h7-11,13-15,19,21-22,34,36-39,47,49-51H,3-6,12,16-18,20,23H2,1-2H3,(H,44,48)/t34-,36-,37+,38-,39+/m1/s1
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n/an/a 148n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]-alpha-methyl-D-glucopyranoside uptake by fluorescence polarization assay

Bioorg Med Chem Lett 18: 4944-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.036
BindingDB Entry DOI: 10.7270/Q27944J7
More data for this
Ligand-Target Pair