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null

SMILES: OC(CNCc1ccc(Cl)cc1Cl)c1cccc(O)c1

InChI Key: InChIKey=FDMOJDWENIPPIZ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50265482
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50265482 (CHEMBL4071661) Show SMILES OC(CNCc1ccc(Cl)cc1Cl)c1cccc(O)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	83	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern California Curated by ChEMBL					Assay Description Displacement of 3H-U69593 from human KOR expressed in HEK293 cells after 90 mins by micro beta scintillation counting analysis				J Med Chem 60: 3070-3081 (2017) Article DOI: 10.1021/acs.jmedchem.7b00109 BindingDB Entry DOI: 10.7270/Q2VQ354M
University of Southern California Curated by ChEMBL					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50265482 (CHEMBL4071661) Show SMILES OC(CNCc1ccc(Cl)cc1Cl)c1cccc(O)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern California Curated by ChEMBL					Assay Description Displacement of 3H-U69593 from human KOR expressed in HEK293 cells after 90 mins by micro beta scintillation counting analysis				J Med Chem 60: 3070-3081 (2017) Article DOI: 10.1021/acs.jmedchem.7b00109 BindingDB Entry DOI: 10.7270/Q2VQ354M
University of Southern California Curated by ChEMBL					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50265482 (CHEMBL4071661) Show SMILES OC(CNCc1ccc(Cl)cc1Cl)c1cccc(O)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	230	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern California Curated by ChEMBL					Assay Description Antagonist activity at KOR (unknown origin) expressed in HTLA cells assessed as inhibition of Sal A-induced beta-arrestin recruitment preincubated fo...				J Med Chem 60: 3070-3081 (2017) Article DOI: 10.1021/acs.jmedchem.7b00109 BindingDB Entry DOI: 10.7270/Q2VQ354M
University of Southern California Curated by ChEMBL					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50265482 (CHEMBL4071661) Show SMILES OC(CNCc1ccc(Cl)cc1Cl)c1cccc(O)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	234	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern California Curated by ChEMBL					Assay Description Antagonist activity at KOR (unknown origin) expressed in HTLA cells assessed as inhibition of Sal A-induced beta-arrestin recruitment preincubated fo...				J Med Chem 60: 3070-3081 (2017) Article DOI: 10.1021/acs.jmedchem.7b00109 BindingDB Entry DOI: 10.7270/Q2VQ354M
University of Southern California Curated by ChEMBL					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50265482 (CHEMBL4071661) Show SMILES OC(CNCc1ccc(Cl)cc1Cl)c1cccc(O)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern California Curated by ChEMBL					Assay Description Antagonist activity at KOR (unknown origin) expressed in HTLA cells assessed as inhibition of Sal A-induced beta-arrestin recruitment preincubated fo...				J Med Chem 60: 3070-3081 (2017) Article DOI: 10.1021/acs.jmedchem.7b00109 BindingDB Entry DOI: 10.7270/Q2VQ354M
University of Southern California Curated by ChEMBL					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50265482 (CHEMBL4071661) Show SMILES OC(CNCc1ccc(Cl)cc1Cl)c1cccc(O)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Southern California Curated by ChEMBL					Assay Description Antagonist activity at KOR (unknown origin) expressed in HTLA cells assessed as inhibition of Sal A-induced beta-arrestin recruitment preincubated fo...				J Med Chem 60: 3070-3081 (2017) Article DOI: 10.1021/acs.jmedchem.7b00109 BindingDB Entry DOI: 10.7270/Q2VQ354M
University of Southern California Curated by ChEMBL					More data for this Ligand-Target Pair