BDBM50265588 CHEMBL4090004

SMILES: Clc1ccc(cc1)C1CN(CCN1C(=O)c1ccccc1)C(=O)c1cnc(o1)-c1ccccc1

InChI Key: InChIKey=KILPQMZYUYRSQV-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50265588   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Eukaryotic initiation factor 4A-III (Homo sapiens (Human))	BDBM50265588 (CHEMBL4090004) Show SMILES Clc1ccc(cc1)C1CN(CCN1C(=O)c1ccccc1)C(=O)c1cnc(o1)-c1ccccc1 Show InChI InChI=1S/C27H22ClN3O3/c28-22-13-11-19(12-14-22)23-18-30(15-16-31(23)26(32)21-9-5-2-6-10-21)27(33)24-17-29-25(34-24)20-7-3-1-4-8-20/h1-14,17,23H,15-16,18H2	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of MLN51-induced full-length human recombinant His6-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia coli BL21(DE3) us...				J Med Chem 60: 3335-3351 (2017) Article DOI: 10.1021/acs.jmedchem.6b01904 BindingDB Entry DOI: 10.7270/Q2GH9MFT
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