BDBM50265605 CHEMBL4083304

SMILES: CCNC(=O)Nc1ccc(Oc2ccccc2)c(c1)-c1nn(C)c(=O)cc1OC

InChI Key: InChIKey=OOWKSWYUEJOQPM-UHFFFAOYSA-N

Data: 1 KI  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50265605   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM50265605 (CHEMBL4083304) Show SMILES CCNC(=O)Nc1ccc(Oc2ccccc2)c(c1)-c1nn(C)c(=O)cc1OC Show InChI InChI=1S/C21H22N4O4/c1-4-22-21(27)23-14-10-11-17(29-15-8-6-5-7-9-15)16(12-14)20-18(28-3)13-19(26)25(2)24-20/h5-13H,4H2,1-3H3,(H2,22,23,27)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie Inc. Curated by ChEMBL					Assay Description Inhibition of human N-terminal His6-tagged BRD4 BD1-BD2 (57 to 550 residues) expressed in EScherichia coli BL21(DE3) after 1 hr by Alexa-647-conjugat...				J Med Chem 60: 3828-3850 (2017) Article DOI: 10.1021/acs.jmedchem.7b00017 BindingDB Entry DOI: 10.7270/Q2BR8VPN
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM50265605 (CHEMBL4083304) Show SMILES CCNC(=O)Nc1ccc(Oc2ccccc2)c(c1)-c1nn(C)c(=O)cc1OC Show InChI InChI=1S/C21H22N4O4/c1-4-22-21(27)23-14-10-11-17(29-15-8-6-5-7-9-15)16(12-14)20-18(28-3)13-19(26)25(2)24-20/h5-13H,4H2,1-3H3,(H2,22,23,27)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a
AbbVie Inc. Curated by ChEMBL					Assay Description Inhibition of BRD4 in human NCI-H1299 cells after 24 hrs by Bright-Glo luciferase reporter gene assay				J Med Chem 60: 3828-3850 (2017) Article DOI: 10.1021/acs.jmedchem.7b00017 BindingDB Entry DOI: 10.7270/Q2BR8VPN
					More data for this Ligand-Target Pair