BDBM50266117 1-(3-methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yloxy)phenyl)-3-phenylurea::CHEMBL517559
SMILES: CNc1nccc(n1)-c1cccnc1Oc1ccc(NC(=O)Nc2ccccc2)cc1C
InChI Key: InChIKey=SNOXVTGWCWHMIO-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 50266117 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50266117
(1-(3-methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)py...)Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(NC(=O)Nc2ccccc2)cc1C Show InChI InChI=1S/C24H22N6O2/c1-16-15-18(29-24(31)28-17-7-4-3-5-8-17)10-11-21(16)32-22-19(9-6-13-26-22)20-12-14-27-23(25-2)30-20/h3-15H,1-2H3,(H,25,27,30)(H2,28,29,31) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 7.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of KDR |
Bioorg Med Chem Lett 19: 424-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.056
BindingDB Entry DOI: 10.7270/Q29P31HK |
More data for this
Ligand-Target Pair | |
Angiopoietin-1 receptor
(Homo sapiens (Human)) | BDBM50266117
(1-(3-methyl-4-(3-(2-(methylamino)pyrimidin-4-yl)py...)Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(NC(=O)Nc2ccccc2)cc1C Show InChI InChI=1S/C24H22N6O2/c1-16-15-18(29-24(31)28-17-7-4-3-5-8-17)10-11-21(16)32-22-19(9-6-13-26-22)20-12-14-27-23(25-2)30-20/h3-15H,1-2H3,(H,25,27,30)(H2,28,29,31) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 460 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description
Inhibition of Tie2 (unknown origin) |
Bioorg Med Chem Lett 19: 424-7 (2008)
Article DOI: 10.1016/j.bmcl.2008.11.056
BindingDB Entry DOI: 10.7270/Q29P31HK |
More data for this
Ligand-Target Pair | |
Search and Browse
