BDBM50266593 CHEMBL477019::{2,4-Dioxo-5-[(6-isopropyl-4-oxo-4H-chromen-3-yl)methylene]-1,3-thiazolidine-3yl}acetic acid

SMILES: CC(C)c1ccc2occ(\C=C3\SC(=O)N(CC(O)=O)C3=O)c(=O)c2c1

InChI Key: InChIKey=WGCTVQMPMURMOT-MKMNVTDBSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50266593   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aldose reductase (Rattus norvegicus)	BDBM50266593 (CHEMBL477019 | {2,4-Dioxo-5-[(6-isopropyl-4-oxo-4H...) Show SMILES CC(C)c1ccc2occ(\C=C3\SC(=O)N(CC(O)=O)C3=O)c(=O)c2c1 Show InChI InChI=1S/C18H15NO6S/c1-9(2)10-3-4-13-12(5-10)16(22)11(8-25-13)6-14-17(23)19(7-15(20)21)18(24)26-14/h3-6,8-9H,7H2,1-2H3,(H,20,21)/b14-6+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	522	n/a	n/a	n/a	n/a	n/a	n/a
Ankara University Curated by ChEMBL					Assay Description Inhibition of aldose reductase in Albino rat kidney assessed as decrease in NADPH concentration by spectrophotometrically				Eur J Med Chem 43: 2412-7 (2008) Article DOI: 10.1016/j.ejmech.2008.01.004 BindingDB Entry DOI: 10.7270/Q2CZ36XD
					More data for this Ligand-Target Pair