BDBM50266839 CHEMBL4071963

SMILES: Cl.NCc1cc(Oc2cccc(c2)C(=O)N2CC[C@@H](O)C2)nc(c1)C(F)(F)F

InChI Key: InChIKey=FJFFHTJCAMKGQO-BTQNPOSSSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50266839   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysyl oxidase homolog 2 (Homo sapiens (Human))	BDBM50266839 (CHEMBL4071963) Show SMILES Cl.NCc1cc(Oc2cccc(c2)C(=O)N2CC[C@@H](O)C2)nc(c1)C(F)(F)F |r| Show InChI InChI=1S/C18H18F3N3O3.ClH/c19-18(20,21)15-6-11(9-22)7-16(23-15)27-14-3-1-2-12(8-14)17(26)24-5-4-13(25)10-24;/h1-3,6-8,13,25H,4-5,9-10,22H2;1H/t13-;/m1./s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	910	n/a	n/a	n/a	n/a	n/a	n/a
PharmAkea Therapeutics Curated by ChEMBL					Assay Description Inhibition of recombinant human LOXL2 expressed in human whole blood assessed as reduction of H2O2 production from oxidative deamination of DAP prein...				J Med Chem 60: 4403-4423 (2017) Article DOI: 10.1021/acs.jmedchem.7b00345 BindingDB Entry DOI: 10.7270/Q2QV3Q0K
					More data for this Ligand-Target Pair
Lysyl oxidase (Homo sapiens (Human))	BDBM50266839 (CHEMBL4071963) Show SMILES Cl.NCc1cc(Oc2cccc(c2)C(=O)N2CC[C@@H](O)C2)nc(c1)C(F)(F)F |r| Show InChI InChI=1S/C18H18F3N3O3.ClH/c19-18(20,21)15-6-11(9-22)7-16(23-15)27-14-3-1-2-12(8-14)17(26)24-5-4-13(25)10-24;/h1-3,6-8,13,25H,4-5,9-10,22H2;1H/t13-;/m1./s1	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
PharmAkea Therapeutics Curated by ChEMBL					Assay Description Inhibition of human LOX expressed in HEK cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs foll...				J Med Chem 60: 4403-4423 (2017) Article DOI: 10.1021/acs.jmedchem.7b00345 BindingDB Entry DOI: 10.7270/Q2QV3Q0K
					More data for this Ligand-Target Pair
Lysyl oxidase homolog 2 (Homo sapiens (Human))	BDBM50266839 (CHEMBL4071963) Show SMILES Cl.NCc1cc(Oc2cccc(c2)C(=O)N2CC[C@@H](O)C2)nc(c1)C(F)(F)F |r| Show InChI InChI=1S/C18H18F3N3O3.ClH/c19-18(20,21)15-6-11(9-22)7-16(23-15)27-14-3-1-2-12(8-14)17(26)24-5-4-13(25)10-24;/h1-3,6-8,13,25H,4-5,9-10,22H2;1H/t13-;/m1./s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
PharmAkea Therapeutics Curated by ChEMBL					Assay Description Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...				J Med Chem 60: 4403-4423 (2017) Article DOI: 10.1021/acs.jmedchem.7b00345 BindingDB Entry DOI: 10.7270/Q2QV3Q0K
					More data for this Ligand-Target Pair
Lysyl oxidase homolog 2 (Homo sapiens (Human))	BDBM50266839 (CHEMBL4071963) Show SMILES Cl.NCc1cc(Oc2cccc(c2)C(=O)N2CC[C@@H](O)C2)nc(c1)C(F)(F)F |r| Show InChI InChI=1S/C18H18F3N3O3.ClH/c19-18(20,21)15-6-11(9-22)7-16(23-15)27-14-3-1-2-12(8-14)17(26)24-5-4-13(25)10-24;/h1-3,6-8,13,25H,4-5,9-10,22H2;1H/t13-;/m1./s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
PharmAkea Therapeutics Curated by ChEMBL					Assay Description Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...				J Med Chem 60: 4403-4423 (2017) Article DOI: 10.1021/acs.jmedchem.7b00345 BindingDB Entry DOI: 10.7270/Q2QV3Q0K
					More data for this Ligand-Target Pair