BDBM50266912 CHEMBL4089892
SMILES: OCCCCc1nc(c([nH]1)-c1ccnc2[nH]c(cc12)-c1ccccc1)-c1ccc(F)cc1
InChI Key: InChIKey=UVBXNSDEQMCSMK-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM50266912 (CHEMBL4089892) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard Karls Universit£t T£bingen Curated by ChEMBL | Assay Description Inhibition of p38alpha MAPK (unknown origin) assessed as decrease in ATF2 phosphorylation at Thr69/71 at 1 uM after 1 hr by ELISA | J Med Chem 60: 4636-4656 (2017) Article DOI: 10.1021/acs.jmedchem.7b00178 BindingDB Entry DOI: 10.7270/Q26T0Q47 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor (Homo sapiens (Human)) | BDBM50266912 (CHEMBL4089892) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Eberhard Karls Universit£t T£bingen Curated by ChEMBL | Assay Description Inhibition of recombinant human GST-tagged wild type EGFR ( 668 to 1210 residues) cytoplasmic domain expressed in baculovirus expression system prein... | J Med Chem 60: 4636-4656 (2017) Article DOI: 10.1021/acs.jmedchem.7b00178 BindingDB Entry DOI: 10.7270/Q26T0Q47 | |||||||||||
More data for this Ligand-Target Pair |