BDBM50267292 CHEMBL4080934

SMILES: COc1cc(N2CC(CCN(C)C)C2)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cn2CCCc3cccc1c23

InChI Key: InChIKey=SDOHWHFANSPDAN-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50267292   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50267292 (CHEMBL4080934) Show SMILES COc1cc(N2CC(CCN(C)C)C2)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cn2CCCc3cccc1c23 Show InChI InChI=1S/C32H37N7O2/c1-5-30(40)34-26-16-27(29(41-4)17-28(26)39-18-21(19-39)12-15-37(2)3)36-32-33-13-11-25(35-32)24-20-38-14-7-9-22-8-6-10-23(24)31(22)38/h5-6,8,10-11,13,16-17,20-21H,1,7,9,12,14-15,18-19H2,2-4H3,(H,34,40)(H,33,35,36)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	251	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing Normal University Curated by ChEMBL					Assay Description Inhibition of human recombinant cytoplasmic GST-tagged EGFR (668 to 1210 residues) expressed in baculovirus using TK-substrate-biotin preincubated fo...				Eur J Med Chem 135: 12-23 (2017) Article DOI: 10.1016/j.ejmech.2017.04.036 BindingDB Entry DOI: 10.7270/Q28P630H
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