BDBM50268294 CHEMBL520148::morpholino(5-(1-(oxetan-3-yl)piperidin-4-yloxy)-1-(2,2,2-trifluoroethyl)-1H-indol-2-yl)methanone

SMILES: FC(F)(F)Cn1c(cc2cc(OC3CCN(CC3)C3COC3)ccc12)C(=O)N1CCOCC1

InChI Key: InChIKey=NALLSZVAKUVBSZ-UHFFFAOYSA-N

Data: 2 KI  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50268294   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50268294 (CHEMBL520148 | morpholino(5-(1-(oxetan-3-yl)piperi...) Show SMILES FC(F)(F)Cn1c(cc2cc(OC3CCN(CC3)C3COC3)ccc12)C(=O)N1CCOCC1 Show InChI InChI=1S/C23H28F3N3O4/c24-23(25,26)15-29-20-2-1-19(33-18-3-5-27(6-4-18)17-13-32-14-17)11-16(20)12-21(29)22(30)28-7-9-31-10-8-28/h1-2,11-12,17-18H,3-10,13-15H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	13	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Displacement of [3H](R)-alpha-methylhistamine from rat recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation counting				J Med Chem 52: 3855-68 (2009) Article DOI: 10.1021/jm900409x BindingDB Entry DOI: 10.7270/Q2SB46NQ
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50268294 (CHEMBL520148 | morpholino(5-(1-(oxetan-3-yl)piperi...) Show SMILES FC(F)(F)Cn1c(cc2cc(OC3CCN(CC3)C3COC3)ccc12)C(=O)N1CCOCC1 Show InChI InChI=1S/C23H28F3N3O4/c24-23(25,26)15-29-20-2-1-19(33-18-3-5-27(6-4-18)17-13-32-14-17)11-16(20)12-21(29)22(30)28-7-9-31-10-8-28/h1-2,11-12,17-18H,3-10,13-15H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	23	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Displacement of [3H](R)-alpha-methylhistamine from human recombinant histamine H3 receptor expressed in CHO cells by liquid scintillation counting				J Med Chem 52: 3855-68 (2009) Article DOI: 10.1021/jm900409x BindingDB Entry DOI: 10.7270/Q2SB46NQ
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50268294 (CHEMBL520148 | morpholino(5-(1-(oxetan-3-yl)piperi...) Show SMILES FC(F)(F)Cn1c(cc2cc(OC3CCN(CC3)C3COC3)ccc12)C(=O)N1CCOCC1 Show InChI InChI=1S/C23H28F3N3O4/c24-23(25,26)15-29-20-2-1-19(33-18-3-5-27(6-4-18)17-13-32-14-17)11-16(20)12-21(29)22(30)28-7-9-31-10-8-28/h1-2,11-12,17-18H,3-10,13-15H2	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	9	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Inverse agonist activity at human histamine H3 receptor expressed in CHO cells by GTPgamma[35S] binding assay				J Med Chem 52: 3855-68 (2009) Article DOI: 10.1021/jm900409x BindingDB Entry DOI: 10.7270/Q2SB46NQ
					More data for this Ligand-Target Pair