Found 8 hits for monomerid = 50268795 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50268795
(Ac-Nle-c[Asp-trans-4-guanidinyl-Pro-DPhe-Arg-Trp-L...)Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@H](CN2C1=O)N=C(N)N)C(N)=O |r,wU:4.4,50.52,63.72,12.11,21.76,wD:25.25,39.41,61.68,(21.05,-10.24,;19.69,-9.52,;19.64,-7.97,;18.28,-7.25,;18.23,-5.71,;19.54,-4.89,;19.48,-3.35,;20.79,-2.54,;18.13,-2.63,;16.87,-4.98,;16.82,-3.44,;15.56,-5.8,;14.2,-5.07,;12.89,-5.89,;12.94,-7.43,;14.3,-8.15,;11.63,-8.24,;10.27,-7.52,;8.96,-8.33,;7.6,-7.6,;6.29,-8.41,;4.93,-7.69,;4.88,-6.15,;3.52,-5.42,;2.21,-6.24,;3.47,-3.88,;2.1,-3.15,;.64,-3.65,;-.62,-2.76,;-1.85,-3.68,;-1.35,-5.15,;-2.08,-6.49,;-1.28,-7.8,;.26,-7.76,;.99,-6.41,;.19,-5.12,;4.78,-3.07,;6.1,-3.3,;7.43,-4.09,;4.73,-1.52,;3.37,-.8,;3.32,.74,;1.96,1.47,;1.91,3.01,;.54,3.73,;.5,5.28,;-.76,2.92,;6.03,-.71,;7.4,-1.43,;7.45,-2.98,;8.71,-.62,;8.66,.92,;7.3,1.65,;7.25,3.18,;5.89,3.91,;4.58,3.1,;4.63,1.55,;5.98,.83,;10.06,-1.35,;11.38,-.54,;11.33,1.01,;12.75,-1.27,;13.83,-.17,;15.32,-.56,;15.32,-2.1,;12.78,-2.79,;14.15,-3.53,;15.45,-2.72,;16.54,.37,;16.34,1.9,;14.92,2.5,;17.57,2.84,;3.63,-8.5,;2.26,-7.78,;3.67,-10.04,)| Show InChI InChI=1S/C50H72N16O9/c1-3-4-16-35(59-28(2)67)43(70)65-39-25-41(68)56-20-11-10-18-34(42(51)69)61-46(73)38(23-30-26-58-33-17-9-8-15-32(30)33)63-44(71)36(19-12-21-57-49(52)53)62-45(72)37(22-29-13-6-5-7-14-29)64-47(74)40-24-31(60-50(54)55)27-66(40)48(39)75/h5-9,13-15,17,26,31,34-40,58H,3-4,10-12,16,18-25,27H2,1-2H3,(H2,51,69)(H,56,68)(H,59,67)(H,61,73)(H,62,72)(H,63,71)(H,64,74)(H,65,70)(H4,52,53,57)(H4,54,55,60)/t31-,34+,35+,36+,37-,38+,39+,40+/m1/s1 | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 14 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Agonist activity at human MC3R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level |
J Med Chem 52: 3627-35 (2009)
Article DOI: 10.1021/jm801300c
BindingDB Entry DOI: 10.7270/Q2D21ZJ5 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50268795
(Ac-Nle-c[Asp-trans-4-guanidinyl-Pro-DPhe-Arg-Trp-L...)Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@H](CN2C1=O)N=C(N)N)C(N)=O |r,wU:4.4,50.52,63.72,12.11,21.76,wD:25.25,39.41,61.68,(21.05,-10.24,;19.69,-9.52,;19.64,-7.97,;18.28,-7.25,;18.23,-5.71,;19.54,-4.89,;19.48,-3.35,;20.79,-2.54,;18.13,-2.63,;16.87,-4.98,;16.82,-3.44,;15.56,-5.8,;14.2,-5.07,;12.89,-5.89,;12.94,-7.43,;14.3,-8.15,;11.63,-8.24,;10.27,-7.52,;8.96,-8.33,;7.6,-7.6,;6.29,-8.41,;4.93,-7.69,;4.88,-6.15,;3.52,-5.42,;2.21,-6.24,;3.47,-3.88,;2.1,-3.15,;.64,-3.65,;-.62,-2.76,;-1.85,-3.68,;-1.35,-5.15,;-2.08,-6.49,;-1.28,-7.8,;.26,-7.76,;.99,-6.41,;.19,-5.12,;4.78,-3.07,;6.1,-3.3,;7.43,-4.09,;4.73,-1.52,;3.37,-.8,;3.32,.74,;1.96,1.47,;1.91,3.01,;.54,3.73,;.5,5.28,;-.76,2.92,;6.03,-.71,;7.4,-1.43,;7.45,-2.98,;8.71,-.62,;8.66,.92,;7.3,1.65,;7.25,3.18,;5.89,3.91,;4.58,3.1,;4.63,1.55,;5.98,.83,;10.06,-1.35,;11.38,-.54,;11.33,1.01,;12.75,-1.27,;13.83,-.17,;15.32,-.56,;15.32,-2.1,;12.78,-2.79,;14.15,-3.53,;15.45,-2.72,;16.54,.37,;16.34,1.9,;14.92,2.5,;17.57,2.84,;3.63,-8.5,;2.26,-7.78,;3.67,-10.04,)| Show InChI InChI=1S/C50H72N16O9/c1-3-4-16-35(59-28(2)67)43(70)65-39-25-41(68)56-20-11-10-18-34(42(51)69)61-46(73)38(23-30-26-58-33-17-9-8-15-32(30)33)63-44(71)36(19-12-21-57-49(52)53)62-45(72)37(22-29-13-6-5-7-14-29)64-47(74)40-24-31(60-50(54)55)27-66(40)48(39)75/h5-9,13-15,17,26,31,34-40,58H,3-4,10-12,16,18-25,27H2,1-2H3,(H2,51,69)(H,56,68)(H,59,67)(H,61,73)(H,62,72)(H,63,71)(H,64,74)(H,65,70)(H4,52,53,57)(H4,54,55,60)/t31-,34+,35+,36+,37-,38+,39+,40+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Displacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC4R expressed in HEK293 cells |
J Med Chem 52: 3627-35 (2009)
Article DOI: 10.1021/jm801300c
BindingDB Entry DOI: 10.7270/Q2D21ZJ5 |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50268795
(Ac-Nle-c[Asp-trans-4-guanidinyl-Pro-DPhe-Arg-Trp-L...)Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@H](CN2C1=O)N=C(N)N)C(N)=O |r,wU:4.4,50.52,63.72,12.11,21.76,wD:25.25,39.41,61.68,(21.05,-10.24,;19.69,-9.52,;19.64,-7.97,;18.28,-7.25,;18.23,-5.71,;19.54,-4.89,;19.48,-3.35,;20.79,-2.54,;18.13,-2.63,;16.87,-4.98,;16.82,-3.44,;15.56,-5.8,;14.2,-5.07,;12.89,-5.89,;12.94,-7.43,;14.3,-8.15,;11.63,-8.24,;10.27,-7.52,;8.96,-8.33,;7.6,-7.6,;6.29,-8.41,;4.93,-7.69,;4.88,-6.15,;3.52,-5.42,;2.21,-6.24,;3.47,-3.88,;2.1,-3.15,;.64,-3.65,;-.62,-2.76,;-1.85,-3.68,;-1.35,-5.15,;-2.08,-6.49,;-1.28,-7.8,;.26,-7.76,;.99,-6.41,;.19,-5.12,;4.78,-3.07,;6.1,-3.3,;7.43,-4.09,;4.73,-1.52,;3.37,-.8,;3.32,.74,;1.96,1.47,;1.91,3.01,;.54,3.73,;.5,5.28,;-.76,2.92,;6.03,-.71,;7.4,-1.43,;7.45,-2.98,;8.71,-.62,;8.66,.92,;7.3,1.65,;7.25,3.18,;5.89,3.91,;4.58,3.1,;4.63,1.55,;5.98,.83,;10.06,-1.35,;11.38,-.54,;11.33,1.01,;12.75,-1.27,;13.83,-.17,;15.32,-.56,;15.32,-2.1,;12.78,-2.79,;14.15,-3.53,;15.45,-2.72,;16.54,.37,;16.34,1.9,;14.92,2.5,;17.57,2.84,;3.63,-8.5,;2.26,-7.78,;3.67,-10.04,)| Show InChI InChI=1S/C50H72N16O9/c1-3-4-16-35(59-28(2)67)43(70)65-39-25-41(68)56-20-11-10-18-34(42(51)69)61-46(73)38(23-30-26-58-33-17-9-8-15-32(30)33)63-44(71)36(19-12-21-57-49(52)53)62-45(72)37(22-29-13-6-5-7-14-29)64-47(74)40-24-31(60-50(54)55)27-66(40)48(39)75/h5-9,13-15,17,26,31,34-40,58H,3-4,10-12,16,18-25,27H2,1-2H3,(H2,51,69)(H,56,68)(H,59,67)(H,61,73)(H,62,72)(H,63,71)(H,64,74)(H,65,70)(H4,52,53,57)(H4,54,55,60)/t31-,34+,35+,36+,37-,38+,39+,40+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 820 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Agonist activity at human MC1R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level |
J Med Chem 52: 3627-35 (2009)
Article DOI: 10.1021/jm801300c
BindingDB Entry DOI: 10.7270/Q2D21ZJ5 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50268795
(Ac-Nle-c[Asp-trans-4-guanidinyl-Pro-DPhe-Arg-Trp-L...)Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@H](CN2C1=O)N=C(N)N)C(N)=O |r,wU:4.4,50.52,63.72,12.11,21.76,wD:25.25,39.41,61.68,(21.05,-10.24,;19.69,-9.52,;19.64,-7.97,;18.28,-7.25,;18.23,-5.71,;19.54,-4.89,;19.48,-3.35,;20.79,-2.54,;18.13,-2.63,;16.87,-4.98,;16.82,-3.44,;15.56,-5.8,;14.2,-5.07,;12.89,-5.89,;12.94,-7.43,;14.3,-8.15,;11.63,-8.24,;10.27,-7.52,;8.96,-8.33,;7.6,-7.6,;6.29,-8.41,;4.93,-7.69,;4.88,-6.15,;3.52,-5.42,;2.21,-6.24,;3.47,-3.88,;2.1,-3.15,;.64,-3.65,;-.62,-2.76,;-1.85,-3.68,;-1.35,-5.15,;-2.08,-6.49,;-1.28,-7.8,;.26,-7.76,;.99,-6.41,;.19,-5.12,;4.78,-3.07,;6.1,-3.3,;7.43,-4.09,;4.73,-1.52,;3.37,-.8,;3.32,.74,;1.96,1.47,;1.91,3.01,;.54,3.73,;.5,5.28,;-.76,2.92,;6.03,-.71,;7.4,-1.43,;7.45,-2.98,;8.71,-.62,;8.66,.92,;7.3,1.65,;7.25,3.18,;5.89,3.91,;4.58,3.1,;4.63,1.55,;5.98,.83,;10.06,-1.35,;11.38,-.54,;11.33,1.01,;12.75,-1.27,;13.83,-.17,;15.32,-.56,;15.32,-2.1,;12.78,-2.79,;14.15,-3.53,;15.45,-2.72,;16.54,.37,;16.34,1.9,;14.92,2.5,;17.57,2.84,;3.63,-8.5,;2.26,-7.78,;3.67,-10.04,)| Show InChI InChI=1S/C50H72N16O9/c1-3-4-16-35(59-28(2)67)43(70)65-39-25-41(68)56-20-11-10-18-34(42(51)69)61-46(73)38(23-30-26-58-33-17-9-8-15-32(30)33)63-44(71)36(19-12-21-57-49(52)53)62-45(72)37(22-29-13-6-5-7-14-29)64-47(74)40-24-31(60-50(54)55)27-66(40)48(39)75/h5-9,13-15,17,26,31,34-40,58H,3-4,10-12,16,18-25,27H2,1-2H3,(H2,51,69)(H,56,68)(H,59,67)(H,61,73)(H,62,72)(H,63,71)(H,64,74)(H,65,70)(H4,52,53,57)(H4,54,55,60)/t31-,34+,35+,36+,37-,38+,39+,40+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Agonist activity at human MC4R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level |
J Med Chem 52: 3627-35 (2009)
Article DOI: 10.1021/jm801300c
BindingDB Entry DOI: 10.7270/Q2D21ZJ5 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 3
(Homo sapiens (Human)) | BDBM50268795
(Ac-Nle-c[Asp-trans-4-guanidinyl-Pro-DPhe-Arg-Trp-L...)Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@H](CN2C1=O)N=C(N)N)C(N)=O |r,wU:4.4,50.52,63.72,12.11,21.76,wD:25.25,39.41,61.68,(21.05,-10.24,;19.69,-9.52,;19.64,-7.97,;18.28,-7.25,;18.23,-5.71,;19.54,-4.89,;19.48,-3.35,;20.79,-2.54,;18.13,-2.63,;16.87,-4.98,;16.82,-3.44,;15.56,-5.8,;14.2,-5.07,;12.89,-5.89,;12.94,-7.43,;14.3,-8.15,;11.63,-8.24,;10.27,-7.52,;8.96,-8.33,;7.6,-7.6,;6.29,-8.41,;4.93,-7.69,;4.88,-6.15,;3.52,-5.42,;2.21,-6.24,;3.47,-3.88,;2.1,-3.15,;.64,-3.65,;-.62,-2.76,;-1.85,-3.68,;-1.35,-5.15,;-2.08,-6.49,;-1.28,-7.8,;.26,-7.76,;.99,-6.41,;.19,-5.12,;4.78,-3.07,;6.1,-3.3,;7.43,-4.09,;4.73,-1.52,;3.37,-.8,;3.32,.74,;1.96,1.47,;1.91,3.01,;.54,3.73,;.5,5.28,;-.76,2.92,;6.03,-.71,;7.4,-1.43,;7.45,-2.98,;8.71,-.62,;8.66,.92,;7.3,1.65,;7.25,3.18,;5.89,3.91,;4.58,3.1,;4.63,1.55,;5.98,.83,;10.06,-1.35,;11.38,-.54,;11.33,1.01,;12.75,-1.27,;13.83,-.17,;15.32,-.56,;15.32,-2.1,;12.78,-2.79,;14.15,-3.53,;15.45,-2.72,;16.54,.37,;16.34,1.9,;14.92,2.5,;17.57,2.84,;3.63,-8.5,;2.26,-7.78,;3.67,-10.04,)| Show InChI InChI=1S/C50H72N16O9/c1-3-4-16-35(59-28(2)67)43(70)65-39-25-41(68)56-20-11-10-18-34(42(51)69)61-46(73)38(23-30-26-58-33-17-9-8-15-32(30)33)63-44(71)36(19-12-21-57-49(52)53)62-45(72)37(22-29-13-6-5-7-14-29)64-47(74)40-24-31(60-50(54)55)27-66(40)48(39)75/h5-9,13-15,17,26,31,34-40,58H,3-4,10-12,16,18-25,27H2,1-2H3,(H2,51,69)(H,56,68)(H,59,67)(H,61,73)(H,62,72)(H,63,71)(H,64,74)(H,65,70)(H4,52,53,57)(H4,54,55,60)/t31-,34+,35+,36+,37-,38+,39+,40+/m1/s1 | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Displacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC3R expressed in HEK293 cells |
J Med Chem 52: 3627-35 (2009)
Article DOI: 10.1021/jm801300c
BindingDB Entry DOI: 10.7270/Q2D21ZJ5 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5 (MC5R)
(Homo sapiens (Human)) | BDBM50268795
(Ac-Nle-c[Asp-trans-4-guanidinyl-Pro-DPhe-Arg-Trp-L...)Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@H](CN2C1=O)N=C(N)N)C(N)=O |r,wU:4.4,50.52,63.72,12.11,21.76,wD:25.25,39.41,61.68,(21.05,-10.24,;19.69,-9.52,;19.64,-7.97,;18.28,-7.25,;18.23,-5.71,;19.54,-4.89,;19.48,-3.35,;20.79,-2.54,;18.13,-2.63,;16.87,-4.98,;16.82,-3.44,;15.56,-5.8,;14.2,-5.07,;12.89,-5.89,;12.94,-7.43,;14.3,-8.15,;11.63,-8.24,;10.27,-7.52,;8.96,-8.33,;7.6,-7.6,;6.29,-8.41,;4.93,-7.69,;4.88,-6.15,;3.52,-5.42,;2.21,-6.24,;3.47,-3.88,;2.1,-3.15,;.64,-3.65,;-.62,-2.76,;-1.85,-3.68,;-1.35,-5.15,;-2.08,-6.49,;-1.28,-7.8,;.26,-7.76,;.99,-6.41,;.19,-5.12,;4.78,-3.07,;6.1,-3.3,;7.43,-4.09,;4.73,-1.52,;3.37,-.8,;3.32,.74,;1.96,1.47,;1.91,3.01,;.54,3.73,;.5,5.28,;-.76,2.92,;6.03,-.71,;7.4,-1.43,;7.45,-2.98,;8.71,-.62,;8.66,.92,;7.3,1.65,;7.25,3.18,;5.89,3.91,;4.58,3.1,;4.63,1.55,;5.98,.83,;10.06,-1.35,;11.38,-.54,;11.33,1.01,;12.75,-1.27,;13.83,-.17,;15.32,-.56,;15.32,-2.1,;12.78,-2.79,;14.15,-3.53,;15.45,-2.72,;16.54,.37,;16.34,1.9,;14.92,2.5,;17.57,2.84,;3.63,-8.5,;2.26,-7.78,;3.67,-10.04,)| Show InChI InChI=1S/C50H72N16O9/c1-3-4-16-35(59-28(2)67)43(70)65-39-25-41(68)56-20-11-10-18-34(42(51)69)61-46(73)38(23-30-26-58-33-17-9-8-15-32(30)33)63-44(71)36(19-12-21-57-49(52)53)62-45(72)37(22-29-13-6-5-7-14-29)64-47(74)40-24-31(60-50(54)55)27-66(40)48(39)75/h5-9,13-15,17,26,31,34-40,58H,3-4,10-12,16,18-25,27H2,1-2H3,(H2,51,69)(H,56,68)(H,59,67)(H,61,73)(H,62,72)(H,63,71)(H,64,74)(H,65,70)(H4,52,53,57)(H4,54,55,60)/t31-,34+,35+,36+,37-,38+,39+,40+/m1/s1 | UniProtKB/SwissProt
antibodypedia
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| CHEMBL
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UniChem
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| Article
PubMed
| n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Displacement of [125I][Nle4,Dphe7]-alpha-MSH from human MC5R expressed in HEK293 cells |
J Med Chem 52: 3627-35 (2009)
Article DOI: 10.1021/jm801300c
BindingDB Entry DOI: 10.7270/Q2D21ZJ5 |
More data for this
Ligand-Target Pair | |
Melanocyte-stimulating hormone receptor
(Homo sapiens (Human)) | BDBM50268795
(Ac-Nle-c[Asp-trans-4-guanidinyl-Pro-DPhe-Arg-Trp-L...)Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@H](CN2C1=O)N=C(N)N)C(N)=O |r,wU:4.4,50.52,63.72,12.11,21.76,wD:25.25,39.41,61.68,(21.05,-10.24,;19.69,-9.52,;19.64,-7.97,;18.28,-7.25,;18.23,-5.71,;19.54,-4.89,;19.48,-3.35,;20.79,-2.54,;18.13,-2.63,;16.87,-4.98,;16.82,-3.44,;15.56,-5.8,;14.2,-5.07,;12.89,-5.89,;12.94,-7.43,;14.3,-8.15,;11.63,-8.24,;10.27,-7.52,;8.96,-8.33,;7.6,-7.6,;6.29,-8.41,;4.93,-7.69,;4.88,-6.15,;3.52,-5.42,;2.21,-6.24,;3.47,-3.88,;2.1,-3.15,;.64,-3.65,;-.62,-2.76,;-1.85,-3.68,;-1.35,-5.15,;-2.08,-6.49,;-1.28,-7.8,;.26,-7.76,;.99,-6.41,;.19,-5.12,;4.78,-3.07,;6.1,-3.3,;7.43,-4.09,;4.73,-1.52,;3.37,-.8,;3.32,.74,;1.96,1.47,;1.91,3.01,;.54,3.73,;.5,5.28,;-.76,2.92,;6.03,-.71,;7.4,-1.43,;7.45,-2.98,;8.71,-.62,;8.66,.92,;7.3,1.65,;7.25,3.18,;5.89,3.91,;4.58,3.1,;4.63,1.55,;5.98,.83,;10.06,-1.35,;11.38,-.54,;11.33,1.01,;12.75,-1.27,;13.83,-.17,;15.32,-.56,;15.32,-2.1,;12.78,-2.79,;14.15,-3.53,;15.45,-2.72,;16.54,.37,;16.34,1.9,;14.92,2.5,;17.57,2.84,;3.63,-8.5,;2.26,-7.78,;3.67,-10.04,)| Show InChI InChI=1S/C50H72N16O9/c1-3-4-16-35(59-28(2)67)43(70)65-39-25-41(68)56-20-11-10-18-34(42(51)69)61-46(73)38(23-30-26-58-33-17-9-8-15-32(30)33)63-44(71)36(19-12-21-57-49(52)53)62-45(72)37(22-29-13-6-5-7-14-29)64-47(74)40-24-31(60-50(54)55)27-66(40)48(39)75/h5-9,13-15,17,26,31,34-40,58H,3-4,10-12,16,18-25,27H2,1-2H3,(H2,51,69)(H,56,68)(H,59,67)(H,61,73)(H,62,72)(H,63,71)(H,64,74)(H,65,70)(H4,52,53,57)(H4,54,55,60)/t31-,34+,35+,36+,37-,38+,39+,40+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Agonist activity at human MC1R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level |
J Med Chem 52: 3627-35 (2009)
Article DOI: 10.1021/jm801300c
BindingDB Entry DOI: 10.7270/Q2D21ZJ5 |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 5 (MC5R)
(Homo sapiens (Human)) | BDBM50268795
(Ac-Nle-c[Asp-trans-4-guanidinyl-Pro-DPhe-Arg-Trp-L...)Show SMILES CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2C[C@H](CN2C1=O)N=C(N)N)C(N)=O |r,wU:4.4,50.52,63.72,12.11,21.76,wD:25.25,39.41,61.68,(21.05,-10.24,;19.69,-9.52,;19.64,-7.97,;18.28,-7.25,;18.23,-5.71,;19.54,-4.89,;19.48,-3.35,;20.79,-2.54,;18.13,-2.63,;16.87,-4.98,;16.82,-3.44,;15.56,-5.8,;14.2,-5.07,;12.89,-5.89,;12.94,-7.43,;14.3,-8.15,;11.63,-8.24,;10.27,-7.52,;8.96,-8.33,;7.6,-7.6,;6.29,-8.41,;4.93,-7.69,;4.88,-6.15,;3.52,-5.42,;2.21,-6.24,;3.47,-3.88,;2.1,-3.15,;.64,-3.65,;-.62,-2.76,;-1.85,-3.68,;-1.35,-5.15,;-2.08,-6.49,;-1.28,-7.8,;.26,-7.76,;.99,-6.41,;.19,-5.12,;4.78,-3.07,;6.1,-3.3,;7.43,-4.09,;4.73,-1.52,;3.37,-.8,;3.32,.74,;1.96,1.47,;1.91,3.01,;.54,3.73,;.5,5.28,;-.76,2.92,;6.03,-.71,;7.4,-1.43,;7.45,-2.98,;8.71,-.62,;8.66,.92,;7.3,1.65,;7.25,3.18,;5.89,3.91,;4.58,3.1,;4.63,1.55,;5.98,.83,;10.06,-1.35,;11.38,-.54,;11.33,1.01,;12.75,-1.27,;13.83,-.17,;15.32,-.56,;15.32,-2.1,;12.78,-2.79,;14.15,-3.53,;15.45,-2.72,;16.54,.37,;16.34,1.9,;14.92,2.5,;17.57,2.84,;3.63,-8.5,;2.26,-7.78,;3.67,-10.04,)| Show InChI InChI=1S/C50H72N16O9/c1-3-4-16-35(59-28(2)67)43(70)65-39-25-41(68)56-20-11-10-18-34(42(51)69)61-46(73)38(23-30-26-58-33-17-9-8-15-32(30)33)63-44(71)36(19-12-21-57-49(52)53)62-45(72)37(22-29-13-6-5-7-14-29)64-47(74)40-24-31(60-50(54)55)27-66(40)48(39)75/h5-9,13-15,17,26,31,34-40,58H,3-4,10-12,16,18-25,27H2,1-2H3,(H2,51,69)(H,56,68)(H,59,67)(H,61,73)(H,62,72)(H,63,71)(H,64,74)(H,65,70)(H4,52,53,57)(H4,54,55,60)/t31-,34+,35+,36+,37-,38+,39+,40+/m1/s1 | UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Agonist activity at human MC5R expressed in HEK293 cells assessed as stimulation of intracellular cAMP level |
J Med Chem 52: 3627-35 (2009)
Article DOI: 10.1021/jm801300c
BindingDB Entry DOI: 10.7270/Q2D21ZJ5 |
More data for this
Ligand-Target Pair | |
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