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BDBM50268820 CHEMBL4102033

SMILES: Cc1ccc(OCC(=O)N(Cc2cccs2)c2ncccn2)cc1

InChI Key: InChIKey=YXIRTQYLYNHHPW-UHFFFAOYSA-N

Data: 1 EC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50268820   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transient receptor potential cation channel subfamily M member 8 (TRPM8)


(Homo sapiens (Human))		BDBM50268820
PNG
(CHEMBL4102033)
Show SMILES Cc1ccc(OCC(=O)N(Cc2cccs2)c2ncccn2)cc1
Show InChI InChI=1S/C18H17N3O2S/c1-14-5-7-15(8-6-14)23-13-17(22)21(12-16-4-2-11-24-16)18-19-9-3-10-20-18/h2-11H,12-13H2,1H3
KEGG

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Article
PubMed
n/an/an/an/a 3.70E+3n/an/an/an/a



Senomyx Inc., 4767 Nexus Centre Dr, San Diego, CA 92121, United States.

Curated by ChEMBL


Assay Description
Agonist activity at human TRPM8 expressed in HEK293 cells assessed as increase in intracellular calcium level after 15 mins by Fluo-3-AM dye-based fl...

Bioorg Med Chem Lett 27: 3931-3938 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.003
BindingDB Entry DOI: 10.7270/Q25H7JRG
More data for this
Ligand-Target Pair