BDBM50269477 CHEMBL4070575

SMILES: Cl.COc1cc(F)ccc1C1CN(CCN1Cc1ccccc1)c1nc(cc(=O)n1C)-c1ccncc1

InChI Key: InChIKey=CYEIYMGISCKXNV-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50269477   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50269477 (CHEMBL4070575) Show SMILES Cl.COc1cc(F)ccc1C1CN(CCN1Cc1ccccc1)c1nc(cc(=O)n1C)-c1ccncc1 Show InChI InChI=1S/C28H28FN5O2.ClH/c1-32-27(35)17-24(21-10-12-30-13-11-21)31-28(32)34-15-14-33(18-20-6-4-3-5-7-20)25(19-34)23-9-8-22(29)16-26(23)36-2;/h3-13,16-17,25H,14-15,18-19H2,1-2H3;1H	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 1000 Kamoshida-cho, Aoba-ku, Yokohama 227-0033, Japan. Curated by ChEMBL					Assay Description Inhibition of recombinant human GSK-3beta using prephosphorylated GS-1 peptide as substrate after 1 hr in presence of [gamma-32P]ATP by liquid scinti...				Bioorg Med Chem Lett 27: 3726-3732 (2017) Article DOI: 10.1016/j.bmcl.2017.06.078 BindingDB Entry DOI: 10.7270/Q2T43WKZ
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