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BDBM50269500 CHEMBL4092858

SMILES: COc1cc2c(Oc3ccc(NC(=O)c4nc5ccccc5n(-c5ccccc5F)c4=O)cc3F)ccnc2cc1OCCCN1CCOCC1

InChI Key: InChIKey=LDPSTPXLWVVSEJ-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50269500   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50269500
PNG
(CHEMBL4092858)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nc5ccccc5n(-c5ccccc5F)c4=O)cc3F)ccnc2cc1OCCCN1CCOCC1 |(8.56,-11.36,;9.9,-10.59,;11.23,-11.36,;12.56,-10.59,;13.89,-11.35,;15.22,-10.58,;15.21,-9.04,;16.54,-8.26,;17.87,-9.03,;19.2,-8.25,;19.19,-6.71,;20.52,-5.93,;21.86,-6.69,;21.87,-8.23,;23.19,-5.91,;23.17,-4.38,;24.51,-3.6,;24.5,-2.07,;25.82,-1.3,;27.16,-2.06,;27.16,-3.6,;25.84,-4.37,;25.85,-5.91,;27.18,-6.67,;27.19,-8.21,;28.52,-8.97,;29.86,-8.19,;29.84,-6.65,;28.51,-5.89,;28.49,-4.35,;24.52,-6.68,;24.53,-8.22,;17.84,-5.95,;16.52,-6.73,;15.18,-5.97,;16.56,-11.34,;16.57,-12.89,;15.23,-13.66,;13.89,-12.89,;12.56,-13.67,;11.23,-12.9,;9.89,-13.67,;8.56,-12.9,;7.23,-13.67,;5.89,-12.9,;4.56,-13.67,;3.23,-12.89,;1.9,-13.66,;1.89,-15.2,;3.22,-15.97,;4.57,-15.21,)|
Show InChI InChI=1S/C38H33F2N5O6/c1-48-34-22-25-29(23-35(34)50-18-6-15-44-16-19-49-20-17-44)41-14-13-32(25)51-33-12-11-24(21-27(33)40)42-37(46)36-38(47)45(30-9-4-2-7-26(30)39)31-10-5-3-8-28(31)43-36/h2-5,7-14,21-23H,6,15-20H2,1H3,(H,42,46)
PDB
MMDB

KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.5n/an/an/an/an/an/a



Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education, 103 Wenhua Road, Shenhe District, Shenyang 110016, PR China; College of Pharma

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 as substrate after 30 mins by HTRF assay

Bioorg Med Chem 25: 4475-4486 (2017)


Article DOI: 10.1016/j.bmc.2017.06.037
BindingDB Entry DOI: 10.7270/Q2PC34W2
More data for this
Ligand-Target Pair