BDBM50269752 CHEMBL4078903

SMILES: O[C@]1(Cc2cc(on2)-c2ccc(=O)[nH]c2)CC[C@H](Cc2ccc(Cl)cc2)CC1

InChI Key: InChIKey=BSUQWSWGPSJBIV-MIRVZWSXSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50269752   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50269752 (CHEMBL4078903) Show SMILES O[C@]1(Cc2cc(on2)-c2ccc(=O)[nH]c2)CC[C@H](Cc2ccc(Cl)cc2)CC1 |r,wD:1.0,17.19,(15.69,-7.67,;16.46,-9,;14.92,-9,;14.15,-10.33,;12.62,-10.49,;12.3,-12,;13.63,-12.77,;14.77,-11.74,;10.89,-12.62,;9.65,-11.72,;8.25,-12.34,;8.08,-13.87,;6.67,-14.5,;9.34,-14.78,;10.74,-14.15,;17.79,-8.22,;19.12,-9,;19.12,-10.54,;20.45,-11.31,;21.78,-10.54,;23.11,-11.32,;24.45,-10.55,;24.45,-9.01,;25.78,-8.24,;23.11,-8.24,;21.78,-9.01,;17.79,-11.3,;16.46,-10.54,)| Show InChI InChI=1S/C22H23ClN2O3/c23-18-4-1-15(2-5-18)11-16-7-9-22(27,10-8-16)13-19-12-20(28-25-19)17-3-6-21(26)24-14-17/h1-6,12,14,16,27H,7-11,13H2,(H,24,26)/t16-,22+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50269752 (CHEMBL4078903) Show SMILES O[C@]1(Cc2cc(on2)-c2ccc(=O)[nH]c2)CC[C@H](Cc2ccc(Cl)cc2)CC1 |r,wD:1.0,17.19,(15.69,-7.67,;16.46,-9,;14.92,-9,;14.15,-10.33,;12.62,-10.49,;12.3,-12,;13.63,-12.77,;14.77,-11.74,;10.89,-12.62,;9.65,-11.72,;8.25,-12.34,;8.08,-13.87,;6.67,-14.5,;9.34,-14.78,;10.74,-14.15,;17.79,-8.22,;19.12,-9,;19.12,-10.54,;20.45,-11.31,;21.78,-10.54,;23.11,-11.32,;24.45,-10.55,;24.45,-9.01,;25.78,-8.24,;23.11,-8.24,;21.78,-9.01,;17.79,-11.3,;16.46,-10.54,)| Show InChI InChI=1S/C22H23ClN2O3/c23-18-4-1-15(2-5-18)11-16-7-9-22(27,10-8-16)13-19-12-20(28-25-19)17-3-6-21(26)24-14-17/h1-6,12,14,16,27H,7-11,13H2,(H,24,26)/t16-,22+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B in Wistar rat brain membrane after 120 mins by liquid scintillation counting analysis				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair