BDBM50270299 (E)-3-[4'-(1'',3''-Dioxolanyl)-benzylidene]-quinuclidine::CHEMBL478912

SMILES: C1COC(O1)c1ccc(\C=C2\CN3CCC2CC3)cc1

InChI Key: InChIKey=XVNXKIXYFBYGNP-WJDWOHSUSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50270299   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Farnesyltransferase, putative (Leishmania major)	BDBM50270299 ((E)-3-[4'-(1'',3''-Dioxolanyl)-benzylidene]-quinuc...) Show SMILES C1COC(O1)c1ccc(\C=C2\CN3CCC2CC3)cc1 |(30.99,-2.22,;29.45,-2.22,;28.97,-3.68,;30.22,-4.59,;31.46,-3.69,;30.22,-6.13,;31.54,-6.9,;31.55,-8.43,;30.21,-9.2,;30.21,-10.74,;28.88,-11.51,;28.88,-13.05,;27.53,-13.82,;26.2,-13.05,;26.2,-11.5,;27.53,-10.73,;26.81,-12.09,;28.29,-12.49,;28.88,-8.44,;28.88,-6.9,)| Show InChI InChI=1S/C17H21NO2/c1-3-15(17-19-9-10-20-17)4-2-13(1)11-16-12-18-7-5-14(16)6-8-18/h1-4,11,14,17H,5-10,12H2/b16-11-	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Cardiff University Curated by ChEMBL					Assay Description Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter				Antimicrob Agents Chemother 51: 4049-61 (2007) Article DOI: 10.1128/AAC.00205-07 BindingDB Entry DOI: 10.7270/Q2MS3SJZ
					More data for this Ligand-Target Pair
Farnesyltransferase, putative (Leishmania major)	BDBM50270299 ((E)-3-[4'-(1'',3''-Dioxolanyl)-benzylidene]-quinuc...) Show SMILES C1COC(O1)c1ccc(\C=C2\CN3CCC2CC3)cc1 |(30.99,-2.22,;29.45,-2.22,;28.97,-3.68,;30.22,-4.59,;31.46,-3.69,;30.22,-6.13,;31.54,-6.9,;31.55,-8.43,;30.21,-9.2,;30.21,-10.74,;28.88,-11.51,;28.88,-13.05,;27.53,-13.82,;26.2,-13.05,;26.2,-11.5,;27.53,-10.73,;26.81,-12.09,;28.29,-12.49,;28.88,-8.44,;28.88,-6.9,)| Show InChI InChI=1S/C17H21NO2/c1-3-15(17-19-9-10-20-17)4-2-13(1)11-16-12-18-7-5-14(16)6-8-18/h1-4,11,14,17H,5-10,12H2/b16-11-	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Cardiff University Curated by ChEMBL					Assay Description Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter				Antimicrob Agents Chemother 51: 4049-61 (2007) Article DOI: 10.1128/AAC.00205-07 BindingDB Entry DOI: 10.7270/Q2MS3SJZ
					More data for this Ligand-Target Pair