BDBM50271762 CHEMBL484109::N4-(3-Bromophenyl)-6-[2-(2-naphthyl)ethyl]-7Hpyrrolo[2,3-d]pyrimidine-2,4-diamine

SMILES: Nc1nc(Nc2cccc(Br)c2)c2cc(CCc3ccc4ccccc4c3)[nH]c2n1

InChI Key: InChIKey=MPXBINGDRCKJQG-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50271762   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50271762 (CHEMBL484109 | N4-(3-Bromophenyl)-6-[2-(2-naphthyl...) Show SMILES Nc1nc(Nc2cccc(Br)c2)c2cc(CCc3ccc4ccccc4c3)[nH]c2n1 Show InChI InChI=1S/C24H20BrN5/c25-18-6-3-7-19(13-18)27-22-21-14-20(28-23(21)30-24(26)29-22)11-9-15-8-10-16-4-1-2-5-17(16)12-15/h1-8,10,12-14H,9,11H2,(H4,26,27,28,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of EGFR (unknown origin) expressed in human tumor cells				Bioorg Med Chem 16: 5514-28 (2008) Article DOI: 10.1016/j.bmc.2008.04.019 BindingDB Entry DOI: 10.7270/Q2GF0T9D
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50271762 (CHEMBL484109 | N4-(3-Bromophenyl)-6-[2-(2-naphthyl...) Show SMILES Nc1nc(Nc2cccc(Br)c2)c2cc(CCc3ccc4ccccc4c3)[nH]c2n1 Show InChI InChI=1S/C24H20BrN5/c25-18-6-3-7-19(13-18)27-22-21-14-20(28-23(21)30-24(26)29-22)11-9-15-8-10-16-4-1-2-5-17(16)12-15/h1-8,10,12-14H,9,11H2,(H4,26,27,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.37E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of PDGFRbeta (unknown origin) expressed in human tumor cells				Bioorg Med Chem 16: 5514-28 (2008) Article DOI: 10.1016/j.bmc.2008.04.019 BindingDB Entry DOI: 10.7270/Q2GF0T9D
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50271762 (CHEMBL484109 | N4-(3-Bromophenyl)-6-[2-(2-naphthyl...) Show SMILES Nc1nc(Nc2cccc(Br)c2)c2cc(CCc3ccc4ccccc4c3)[nH]c2n1 Show InChI InChI=1S/C24H20BrN5/c25-18-6-3-7-19(13-18)27-22-21-14-20(28-23(21)30-24(26)29-22)11-9-15-8-10-16-4-1-2-5-17(16)12-15/h1-8,10,12-14H,9,11H2,(H4,26,27,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.68E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of VEGFR2 (unknown origin) expressed in human tumor cells				Bioorg Med Chem 16: 5514-28 (2008) Article DOI: 10.1016/j.bmc.2008.04.019 BindingDB Entry DOI: 10.7270/Q2GF0T9D
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM50271762 (CHEMBL484109 | N4-(3-Bromophenyl)-6-[2-(2-naphthyl...) Show SMILES Nc1nc(Nc2cccc(Br)c2)c2cc(CCc3ccc4ccccc4c3)[nH]c2n1 Show InChI InChI=1S/C24H20BrN5/c25-18-6-3-7-19(13-18)27-22-21-14-20(28-23(21)30-24(26)29-22)11-9-15-8-10-16-4-1-2-5-17(16)12-15/h1-8,10,12-14H,9,11H2,(H4,26,27,28,29,30)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Inhibition of VEGFR1 (unknown origin) expressed in human tumor cells				Bioorg Med Chem 16: 5514-28 (2008) Article DOI: 10.1016/j.bmc.2008.04.019 BindingDB Entry DOI: 10.7270/Q2GF0T9D
					More data for this Ligand-Target Pair