BDBM50272217 (E/Z)-4-(2-(1-methyl-4-phenyl-1H-imidazol-5-yl)vinyl)pyrimidin-2-amine::CHEMBL526925

SMILES: Cn1cnc(c1\C=C\c1ccnc(N)n1)-c1ccccc1

InChI Key: InChIKey=ZOBMEONPYSLCBL-BQYQJAHWSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50272217   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50272217 ((E/Z)-4-(2-(1-methyl-4-phenyl-1H-imidazol-5-yl)vin...) Show SMILES Cn1cnc(c1\C=C\c1ccnc(N)n1)-c1ccccc1 Show InChI InChI=1S/C16H15N5/c1-21-11-19-15(12-5-3-2-4-6-12)14(21)8-7-13-9-10-18-16(17)20-13/h2-11H,1H3,(H2,17,18,20)/b8-7+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of recombinant KDR (unknown origin) expressed in baculovirus-Sf21 system				Bioorg Med Chem Lett 18: 4723-6 (2008) Article DOI: 10.1016/j.bmcl.2008.06.106 BindingDB Entry DOI: 10.7270/Q2SJ1KD2
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM50272217 ((E/Z)-4-(2-(1-methyl-4-phenyl-1H-imidazol-5-yl)vin...) Show SMILES Cn1cnc(c1\C=C\c1ccnc(N)n1)-c1ccccc1 Show InChI InChI=1S/C16H15N5/c1-21-11-19-15(12-5-3-2-4-6-12)14(21)8-7-13-9-10-18-16(17)20-13/h2-11H,1H3,(H2,17,18,20)/b8-7+	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of recombinant Flt1 (unknown origin) expressed in baculovirus-Sf21 system				Bioorg Med Chem Lett 18: 4723-6 (2008) Article DOI: 10.1016/j.bmcl.2008.06.106 BindingDB Entry DOI: 10.7270/Q2SJ1KD2
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50272217 ((E/Z)-4-(2-(1-methyl-4-phenyl-1H-imidazol-5-yl)vin...) Show SMILES Cn1cnc(c1\C=C\c1ccnc(N)n1)-c1ccccc1 Show InChI InChI=1S/C16H15N5/c1-21-11-19-15(12-5-3-2-4-6-12)14(21)8-7-13-9-10-18-16(17)20-13/h2-11H,1H3,(H2,17,18,20)/b8-7+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of recombinant Tie2 (unknown origin) expressed in baculovirus-Sf21 system				Bioorg Med Chem Lett 18: 4723-6 (2008) Article DOI: 10.1016/j.bmcl.2008.06.106 BindingDB Entry DOI: 10.7270/Q2SJ1KD2
					More data for this Ligand-Target Pair
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM50272217 ((E/Z)-4-(2-(1-methyl-4-phenyl-1H-imidazol-5-yl)vin...) Show SMILES Cn1cnc(c1\C=C\c1ccnc(N)n1)-c1ccccc1 Show InChI InChI=1S/C16H15N5/c1-21-11-19-15(12-5-3-2-4-6-12)14(21)8-7-13-9-10-18-16(17)20-13/h2-11H,1H3,(H2,17,18,20)/b8-7+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	340	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human Tie2 (unknown origin) autophosphorylation expressed in CHOK1 cells by ELISA				Bioorg Med Chem Lett 18: 4723-6 (2008) Article DOI: 10.1016/j.bmcl.2008.06.106 BindingDB Entry DOI: 10.7270/Q2SJ1KD2
					More data for this Ligand-Target Pair