null

SMILES: Cc1c(-c2cccc(OCCCC(O)=O)c2F)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F

InChI Key: InChIKey=GXMAQGOTQMHUBR-DEOSSOPVSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50272663   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50272663 ((R)-4-(3-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-3...) Show SMILES Cc1c(-c2cccc(OCCCC(O)=O)c2F)c(=O)n(C[C@H](N)c2ccccc2)c(=O)n1Cc1c(F)cccc1C(F)(F)F |r,wD:21.22,(33.83,-41.56,;32.49,-40.79,;32.49,-39.25,;33.82,-38.48,;35.15,-39.26,;36.49,-38.5,;36.5,-36.96,;35.15,-36.18,;35.15,-34.64,;36.49,-33.87,;36.49,-32.33,;37.82,-31.56,;37.82,-30.02,;39.15,-29.25,;36.49,-29.25,;33.82,-36.95,;32.49,-36.18,;31.16,-38.47,;31.16,-36.93,;29.84,-39.25,;28.5,-38.48,;27.17,-39.25,;27.17,-40.79,;25.83,-38.49,;25.84,-36.95,;24.5,-36.18,;23.17,-36.96,;23.18,-38.51,;24.51,-39.27,;29.84,-40.79,;28.5,-41.56,;31.16,-41.55,;31.16,-43.09,;30.38,-44.42,;31.21,-45.7,;32.75,-45.62,;30.52,-47.07,;28.97,-47.15,;28.14,-45.86,;28.84,-44.49,;28.01,-43.19,;27.19,-41.89,;26.71,-44.02,;29.31,-42.36,)| Show InChI InChI=1S/C31H28F5N3O5/c1-18-27(20-10-5-13-25(28(20)33)44-15-7-14-26(40)41)29(42)39(17-24(37)19-8-3-2-4-9-19)30(43)38(18)16-21-22(31(34,35)36)11-6-12-23(21)32/h2-6,8-13,24H,7,14-17,37H2,1H3,(H,40,41)/t24-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Neurocrine Biosciences, Inc. Curated by ChEMBL					Assay Description Displacement of [125I]tyr5,D-Leu6,NMeLeu7-GnRH from human cloned GnRH receptor expressed in RBL cells				Bioorg Med Chem Lett 18: 4503-7 (2008) Article DOI: 10.1016/j.bmcl.2008.07.059 BindingDB Entry DOI: 10.7270/Q2QR4WZJ
					More data for this Ligand-Target Pair