BDBM50273399 4-({2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-methyl-4-oxo-4,5-dihydrothiazol-5-yl}methyl)benzamide::CHEMBL517936

SMILES: C[C@H](NC1=NC(=O)C(C)(Cc2ccc(cc2)C(N)=O)S1)c1ccc(F)cc1

InChI Key: InChIKey=UWEWELHRHRROOB-SVZXGPMESA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50273399   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM50273399 (4-({2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-methyl-...) Show SMILES C[C@H](NC1=NC(=O)C(C)(Cc2ccc(cc2)C(N)=O)S1)c1ccc(F)cc1 |r,t:3| Show InChI InChI=1S/C20H20FN3O2S/c1-12(14-7-9-16(21)10-8-14)23-19-24-18(26)20(2,27-19)11-13-3-5-15(6-4-13)17(22)25/h3-10,12H,11H2,1-2H3,(H2,22,25)(H,23,24,26)/t12-,20?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen, Inc. Curated by ChEMBL					Assay Description Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli using [3H]cortisone by scintillation proximity assay				J Med Chem 51: 7953-67 (2008) Article DOI: 10.1021/jm801073z BindingDB Entry DOI: 10.7270/Q2FJ2GN7
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