BDBM50273546 1-(3,4-Bisdifluoromethoxyphenyl)-3-phenylpropan-1-one::CHEMBL456617

SMILES: FC(F)Oc1ccc(cc1OC(F)F)C(=O)CCc1ccccc1

InChI Key: InChIKey=XQHOSMPOYDBZSO-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50273546   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50273546 (1-(3,4-Bisdifluoromethoxyphenyl)-3-phenylpropan-1-...) Show SMILES FC(F)Oc1ccc(cc1OC(F)F)C(=O)CCc1ccccc1 Show InChI InChI=1S/C17H14F4O3/c18-16(19)23-14-9-7-12(10-15(14)24-17(20)21)13(22)8-6-11-4-2-1-3-5-11/h1-5,7,9-10,16-17H,6,8H2	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	501	n/a	n/a	n/a	n/a	n/a	n/a
Georgia State University Curated by ChEMBL					Assay Description Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting				J Med Chem 51: 7673-88 (2008) Article DOI: 10.1021/jm701635j BindingDB Entry DOI: 10.7270/Q2736QRN
					More data for this Ligand-Target Pair
Phosphodiesterase (TcrPDEC) (Trypanosoma cruzi)	BDBM50273546 (1-(3,4-Bisdifluoromethoxyphenyl)-3-phenylpropan-1-...) Show SMILES FC(F)Oc1ccc(cc1OC(F)F)C(=O)CCc1ccccc1 Show InChI InChI=1S/C17H14F4O3/c18-16(19)23-14-9-7-12(10-15(14)24-17(20)21)13(22)8-6-11-4-2-1-3-5-11/h1-5,7,9-10,16-17H,6,8H2	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Georgia Curated by ChEMBL					Assay Description Inhibition of Trypanosoma cruzi Y PDEC after 30 mins				Antimicrob Agents Chemother 54: 3738-45 (2010) Article DOI: 10.1128/AAC.00313-10 BindingDB Entry DOI: 10.7270/Q21V5F7Z
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM50273546 (1-(3,4-Bisdifluoromethoxyphenyl)-3-phenylpropan-1-...) Show SMILES FC(F)Oc1ccc(cc1OC(F)F)C(=O)CCc1ccccc1 Show InChI InChI=1S/C17H14F4O3/c18-16(19)23-14-9-7-12(10-15(14)24-17(20)21)13(22)8-6-11-4-2-1-3-5-11/h1-5,7,9-10,16-17H,6,8H2	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	501	n/a	n/a	n/a	n/a	n/a	n/a
Georgia State University Curated by ChEMBL					Assay Description Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting				J Med Chem 51: 7673-88 (2008) Article DOI: 10.1021/jm701635j BindingDB Entry DOI: 10.7270/Q2736QRN
					More data for this Ligand-Target Pair