BDBM50273576 1-[4-Difluoromethoxy-3-(tetrahydrofuran-3-yloxy)phenyl]-2,2-dimethylpropan-1-one::CHEMBL456590
SMILES: CC(C)(C)C(=O)c1ccc(OC(F)F)c(OC2CCOC2)c1
InChI Key: InChIKey=VOHSSOAIYIESEX-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human)) | BDBM50273576 (1-[4-Difluoromethoxy-3-(tetrahydrofuran-3-yloxy)ph...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 407 | n/a | n/a | n/a | n/a | n/a | n/a |
Georgia State University Curated by ChEMBL | Assay Description Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting | J Med Chem 51: 7673-88 (2008) Article DOI: 10.1021/jm701635j BindingDB Entry DOI: 10.7270/Q2736QRN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human)) | BDBM50273576 (1-[4-Difluoromethoxy-3-(tetrahydrofuran-3-yloxy)ph...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 407 | n/a | n/a | n/a | n/a | n/a | n/a |
Georgia State University Curated by ChEMBL | Assay Description Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting | J Med Chem 51: 7673-88 (2008) Article DOI: 10.1021/jm701635j BindingDB Entry DOI: 10.7270/Q2736QRN | |||||||||||
More data for this Ligand-Target Pair |