BDBM50273601 4-[3-Methoxy-4-(pyridin-2-yloxy)phenyl]-4-quinolin-3-ylbutan-2-one::CHEMBL457216
SMILES: COc1cc(ccc1Oc1ccccn1)C(CC(C)=O)c1cnc2ccccc2c1
InChI Key: InChIKey=JBATWLGSNPAREQ-UHFFFAOYSA-N
Data: 6 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human)) | BDBM50273601 (4-[3-Methoxy-4-(pyridin-2-yloxy)phenyl]-4-quinolin...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.03E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Georgia State University Curated by ChEMBL | Assay Description Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting | J Med Chem 51: 7673-88 (2008) Article DOI: 10.1021/jm701635j BindingDB Entry DOI: 10.7270/Q2736QRN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM50273601 (4-[3-Methoxy-4-(pyridin-2-yloxy)phenyl]-4-quinolin...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Georgia State University Curated by ChEMBL | Assay Description Inhibition of human cloned PDE5A1 expressed in Escherichia coli BL21 by liquid scintillation counting | J Med Chem 51: 7673-88 (2008) Article DOI: 10.1021/jm701635j BindingDB Entry DOI: 10.7270/Q2736QRN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human)) | BDBM50273601 (4-[3-Methoxy-4-(pyridin-2-yloxy)phenyl]-4-quinolin...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Georgia State University Curated by ChEMBL | Assay Description Inhibition of human cloned PDE2A3 expressed in Escherichia coli BL21 by liquid scintillation counting | J Med Chem 51: 7673-88 (2008) Article DOI: 10.1021/jm701635j BindingDB Entry DOI: 10.7270/Q2736QRN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 7 (Homo sapiens (Human)) | BDBM50273601 (4-[3-Methoxy-4-(pyridin-2-yloxy)phenyl]-4-quinolin...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Georgia State University Curated by ChEMBL | Assay Description Inhibition of human cloned PDE7A1 catalytic domain expressed in Escherichia coli BL21 by liquid scintillation counting | J Med Chem 51: 7673-88 (2008) Article DOI: 10.1021/jm701635j BindingDB Entry DOI: 10.7270/Q2736QRN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 9A (Homo sapiens (Human)) | BDBM50273601 (4-[3-Methoxy-4-(pyridin-2-yloxy)phenyl]-4-quinolin...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Georgia State University Curated by ChEMBL | Assay Description Inhibition of human cloned PDE9A2 expressed in Escherichia coli BL21 by liquid scintillation counting | J Med Chem 51: 7673-88 (2008) Article DOI: 10.1021/jm701635j BindingDB Entry DOI: 10.7270/Q2736QRN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human)) | BDBM50273601 (4-[3-Methoxy-4-(pyridin-2-yloxy)phenyl]-4-quinolin...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.03E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Georgia State University Curated by ChEMBL | Assay Description Inhibition of full length human PDE4D2 expressed in Escherichia coli BL21 by liquid scintillation counting | J Med Chem 51: 7673-88 (2008) Article DOI: 10.1021/jm701635j BindingDB Entry DOI: 10.7270/Q2736QRN | |||||||||||
More data for this Ligand-Target Pair |