BDBM50273716 CHEMBL457423::[2-(Benzoimidazol-1-yl)ethyl]-bisphosphonic acid
SMILES: OP(O)(=O)C(Cn1cnc2ccccc12)P(O)(O)=O
InChI Key: InChIKey=ISSICOMKRRPVPD-UHFFFAOYSA-N
Data: 6 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Farnesyl diphosphate synthase (Homo sapiens (Human)) | BDBM50273716 (CHEMBL457423 | [2-(Benzoimidazol-1-yl)ethyl]-bisph...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 16.1 | n/a | n/a | n/a | n/a | n/a | n/a |
Universita di Ferrara Curated by ChEMBL | Assay Description Inhibition of human FPP synthase expressed in Escherichia coli BL21 (DE3) | J Med Chem 51: 6800-7 (2008) Article DOI: 10.1021/jm801003y BindingDB Entry DOI: 10.7270/Q2F76CD8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl Diphosphate Synthase (GGPPS) (Homo sapiens (Human)) | BDBM50273716 (CHEMBL457423 | [2-(Benzoimidazol-1-yl)ethyl]-bisph...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.05E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Iowa Curated by ChEMBL | Assay Description Inhibition of GGDPS (unknown origin) using [14C] IPP and FPP as substrate preincubated for 10 mins followed by substrate addition and measured after ... | Bioorg Med Chem Lett 29: (2019) Article DOI: 10.1016/j.bmcl.2019.126757 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Geranylgeranyl transferase type-2 subunit alpha (Rattus norvegicus) | BDBM50273716 (CHEMBL457423 | [2-(Benzoimidazol-1-yl)ethyl]-bisph...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Iowa Curated by ChEMBL | Assay Description Inhibition of recombinant rat RabGGTase expressed in Escherichia coli using Rab7 as substrate and [3H]geranylgeranyl pyrophosphate after 20 mins by l... | Bioorg Med Chem Lett 29: (2019) Article DOI: 10.1016/j.bmcl.2019.126757 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit (Rattus norvegicus-Rattus norvegicus (rat)) | BDBM50273716 (CHEMBL457423 | [2-(Benzoimidazol-1-yl)ethyl]-bisph...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 8.30E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Iowa Curated by ChEMBL | Assay Description Inhibition of recombinant rat FTase expressed in Escherichia coli using dansyl-GCVLS as substrate after 1.5 hrs by spectrofluorimetric analysis | Bioorg Med Chem Lett 29: (2019) Article DOI: 10.1016/j.bmcl.2019.126757 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
geranylgeranyltransferase type-I (Rattus norvegicus) | BDBM50273716 (CHEMBL457423 | [2-(Benzoimidazol-1-yl)ethyl]-bisph...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Iowa Curated by ChEMBL | Assay Description Inhibition of recombinant rat GGtase-1 expressed in Escherichia coli using dansyl-GCVLL as substrate after 1.5 hrs by spectrofluorimetric analysis | Bioorg Med Chem Lett 29: (2019) Article DOI: 10.1016/j.bmcl.2019.126757 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Farnesyl diphosphate synthase (Homo sapiens (Human)) | BDBM50273716 (CHEMBL457423 | [2-(Benzoimidazol-1-yl)ethyl]-bisph...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Iowa Curated by ChEMBL | Assay Description Inhibition of FDPS (unknown origin) using [14C] IPP and GPP as substrate preincubated for 10 mins followed by substrate addition and measured after 3... | Bioorg Med Chem Lett 29: (2019) Article DOI: 10.1016/j.bmcl.2019.126757 | |||||||||||
More data for this Ligand-Target Pair |