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BDBM50274578 3-(4-[(1-Butyl-4-piperidinyl)oxy]phenyl)-2-methyl-4(3H)-quinazolinone::CHEMBL484200

SMILES: CCCCN1CCC(CC1)Oc1ccc(cc1)-n1c(C)nc2ccccc2c1=O

InChI Key: InChIKey=FBQZQGMQBBKOGP-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50274578   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50274578
PNG
(3-(4-[(1-Butyl-4-piperidinyl)oxy]phenyl)-2-methyl-...)
Show SMILES CCCCN1CCC(CC1)Oc1ccc(cc1)-n1c(C)nc2ccccc2c1=O
Show InChI InChI=1S/C24H29N3O2/c1-3-4-15-26-16-13-21(14-17-26)29-20-11-9-19(10-12-20)27-18(2)25-23-8-6-5-7-22(23)24(27)28/h5-12,21H,3-4,13-17H2,1-2H3
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 91n/an/an/an/an/an/a



Tsukuba Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human cloned histamine H3 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine-induced [35S]GT...


J Med Chem 51: 6889-901 (2008)


Article DOI: 10.1021/jm800569w
BindingDB Entry DOI: 10.7270/Q27P8Z60
More data for this
Ligand-Target Pair