BDBM50274654 2-Methyl-3-[4-([3-(1-pyrrolidinyl)cyclopentyl]oxy)phenyl]-4(3H)-quinazolinone::CHEMBL484740

SMILES: Cc1nc2ccccc2c(=O)n1-c1ccc(OC2CCC(C2)N2CCCC2)cc1

InChI Key: InChIKey=RWNXKETUEWVUIP-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50274654   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H3 receptor (Homo sapiens (Human))	BDBM50274654 (2-Methyl-3-[4-([3-(1-pyrrolidinyl)cyclopentyl]oxy)...) Show SMILES Cc1nc2ccccc2c(=O)n1-c1ccc(OC2CCC(C2)N2CCCC2)cc1 Show InChI InChI=1S/C24H27N3O2/c1-17-25-23-7-3-2-6-22(23)24(28)27(17)18-8-11-20(12-9-18)29-21-13-10-19(16-21)26-14-4-5-15-26/h2-3,6-9,11-12,19,21H,4-5,10,13-16H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human cloned histamine H3 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine-induced [35S]GT...				J Med Chem 51: 6889-901 (2008) Article DOI: 10.1021/jm800569w BindingDB Entry DOI: 10.7270/Q27P8Z60
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50274654 (2-Methyl-3-[4-([3-(1-pyrrolidinyl)cyclopentyl]oxy)...) Show SMILES Cc1nc2ccccc2c(=O)n1-c1ccc(OC2CCC(C2)N2CCCC2)cc1 Show InChI InChI=1S/C24H27N3O2/c1-17-25-23-7-3-2-6-22(23)24(28)27(17)18-8-11-20(12-9-18)29-21-13-10-19(16-21)26-14-4-5-15-26/h2-3,6-9,11-12,19,21H,4-5,10,13-16H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human ERG in HEK293 cells assessed as inhibition of [35S]N-[(4R)-1'-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthalenyl]-3,4-dihyd...				J Med Chem 51: 6889-901 (2008) Article DOI: 10.1021/jm800569w BindingDB Entry DOI: 10.7270/Q27P8Z60
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50274654 (2-Methyl-3-[4-([3-(1-pyrrolidinyl)cyclopentyl]oxy)...) Show SMILES Cc1nc2ccccc2c(=O)n1-c1ccc(OC2CCC(C2)N2CCCC2)cc1 Show InChI InChI=1S/C24H27N3O2/c1-17-25-23-7-3-2-6-22(23)24(28)27(17)18-8-11-20(12-9-18)29-21-13-10-19(16-21)26-14-4-5-15-26/h2-3,6-9,11-12,19,21H,4-5,10,13-16H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human ERG in HEK293 cells assessed as inhibition of [35S]N-[(4R)-1'-[(2R)-6-cyano-1,2,3,4-tetrahydro-2-naphthalenyl]-3,4-dihyd...				J Med Chem 51: 6889-901 (2008) Article DOI: 10.1021/jm800569w BindingDB Entry DOI: 10.7270/Q27P8Z60
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM50274654 (2-Methyl-3-[4-([3-(1-pyrrolidinyl)cyclopentyl]oxy)...) Show SMILES Cc1nc2ccccc2c(=O)n1-c1ccc(OC2CCC(C2)N2CCCC2)cc1 Show InChI InChI=1S/C24H27N3O2/c1-17-25-23-7-3-2-6-22(23)24(28)27(17)18-8-11-20(12-9-18)29-21-13-10-19(16-21)26-14-4-5-15-26/h2-3,6-9,11-12,19,21H,4-5,10,13-16H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.60	n/a	n/a	n/a	n/a	n/a	n/a
Tsukuba Research Institute Curated by ChEMBL					Assay Description Antagonist activity at human cloned histamine H3 receptor expressed in CHO-K1 cells assessed as inhibition of R-alpha-methylhistamine-induced [35S]GT...				J Med Chem 51: 6889-901 (2008) Article DOI: 10.1021/jm800569w BindingDB Entry DOI: 10.7270/Q27P8Z60
					More data for this Ligand-Target Pair