Found 3 hits for monomerid = 50274931 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Gonadotropin-releasing hormone receptor
(Homo sapiens (Human)) | BDBM50274931
((R)-4-{2-[5-(2-Fluoro-3-methoxyphenyl)-3-(2-chloro...)Show SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2Cl)c(=O)n(C[C@H](NCCCC(O)=O)c2ccccc2)c1=O |r,wD:26.28,(8.1,-10.47,;6.76,-11.23,;5.43,-10.46,;5.44,-8.92,;4.1,-8.14,;2.77,-8.91,;2.77,-10.45,;4.1,-11.22,;4.09,-12.76,;1.44,-11.21,;1.44,-12.75,;2.77,-13.52,;.11,-13.51,;.11,-15.05,;1.44,-15.82,;2.76,-15.05,;4.09,-14.27,;4.1,-15.81,;4.1,-17.36,;2.77,-18.13,;1.43,-17.36,;.1,-18.13,;-1.22,-12.75,;-2.55,-13.52,;-1.22,-11.21,;-2.56,-10.44,;-3.89,-11.22,;-3.88,-12.76,;-5.22,-13.53,;-5.21,-15.07,;-6.54,-15.84,;-6.54,-17.38,;-7.87,-18.16,;-5.2,-18.15,;-5.22,-10.45,;-5.23,-8.91,;-6.57,-8.14,;-7.9,-8.93,;-7.89,-10.46,;-6.56,-11.22,;.11,-10.43,;.11,-8.89,)| Show InChI InChI=1S/C31H30ClF2N3O5/c1-19-28(21-11-6-14-26(42-2)29(21)34)30(40)37(31(41)36(19)17-22-23(32)12-7-13-24(22)33)18-25(20-9-4-3-5-10-20)35-16-8-15-27(38)39/h3-7,9-14,25,35H,8,15-18H2,1-2H3,(H,38,39)/t25-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description Displacement of [125I-Tyr5,DLeu6,NMeLeu7,Pro9-NEt-]GnRH from human GnRH receptor expressed in HEK293 cells by liquid scintillation counting |
J Med Chem 51: 7478-85 (2009)
Article DOI: 10.1021/jm8006454 BindingDB Entry DOI: 10.7270/Q2S46RT8 |
More data for this Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50274931
((R)-4-{2-[5-(2-Fluoro-3-methoxyphenyl)-3-(2-chloro...)Show SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2Cl)c(=O)n(C[C@H](NCCCC(O)=O)c2ccccc2)c1=O |r,wD:26.28,(8.1,-10.47,;6.76,-11.23,;5.43,-10.46,;5.44,-8.92,;4.1,-8.14,;2.77,-8.91,;2.77,-10.45,;4.1,-11.22,;4.09,-12.76,;1.44,-11.21,;1.44,-12.75,;2.77,-13.52,;.11,-13.51,;.11,-15.05,;1.44,-15.82,;2.76,-15.05,;4.09,-14.27,;4.1,-15.81,;4.1,-17.36,;2.77,-18.13,;1.43,-17.36,;.1,-18.13,;-1.22,-12.75,;-2.55,-13.52,;-1.22,-11.21,;-2.56,-10.44,;-3.89,-11.22,;-3.88,-12.76,;-5.22,-13.53,;-5.21,-15.07,;-6.54,-15.84,;-6.54,-17.38,;-7.87,-18.16,;-5.2,-18.15,;-5.22,-10.45,;-5.23,-8.91,;-6.57,-8.14,;-7.9,-8.93,;-7.89,-10.46,;-6.56,-11.22,;.11,-10.43,;.11,-8.89,)| Show InChI InChI=1S/C31H30ClF2N3O5/c1-19-28(21-11-6-14-26(42-2)29(21)34)30(40)37(31(41)36(19)17-22-23(32)12-7-13-24(22)33)18-25(20-9-4-3-5-10-20)35-16-8-15-27(38)39/h3-7,9-14,25,35H,8,15-18H2,1-2H3,(H,38,39)/t25-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description Inhibition of CYP3A4 (unknown origin) |
J Med Chem 51: 7478-85 (2009)
Article DOI: 10.1021/jm8006454 BindingDB Entry DOI: 10.7270/Q2S46RT8 |
More data for this Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Homo sapiens (Human)) | BDBM50274931
((R)-4-{2-[5-(2-Fluoro-3-methoxyphenyl)-3-(2-chloro...)Show SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2Cl)c(=O)n(C[C@H](NCCCC(O)=O)c2ccccc2)c1=O |r,wD:26.28,(8.1,-10.47,;6.76,-11.23,;5.43,-10.46,;5.44,-8.92,;4.1,-8.14,;2.77,-8.91,;2.77,-10.45,;4.1,-11.22,;4.09,-12.76,;1.44,-11.21,;1.44,-12.75,;2.77,-13.52,;.11,-13.51,;.11,-15.05,;1.44,-15.82,;2.76,-15.05,;4.09,-14.27,;4.1,-15.81,;4.1,-17.36,;2.77,-18.13,;1.43,-17.36,;.1,-18.13,;-1.22,-12.75,;-2.55,-13.52,;-1.22,-11.21,;-2.56,-10.44,;-3.89,-11.22,;-3.88,-12.76,;-5.22,-13.53,;-5.21,-15.07,;-6.54,-15.84,;-6.54,-17.38,;-7.87,-18.16,;-5.2,-18.15,;-5.22,-10.45,;-5.23,-8.91,;-6.57,-8.14,;-7.9,-8.93,;-7.89,-10.46,;-6.56,-11.22,;.11,-10.43,;.11,-8.89,)| Show InChI InChI=1S/C31H30ClF2N3O5/c1-19-28(21-11-6-14-26(42-2)29(21)34)30(40)37(31(41)36(19)17-22-23(32)12-7-13-24(22)33)18-25(20-9-4-3-5-10-20)35-16-8-15-27(38)39/h3-7,9-14,25,35H,8,15-18H2,1-2H3,(H,38,39)/t25-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Neurocrine Biosciences, Inc.
Curated by ChEMBL
| Assay Description Antagonist activity at human GnRH receptor expressed in RBL1 cells assessed as inhibition of GnRH-stimulated inositol phosphate production |
J Med Chem 51: 7478-85 (2009)
Article DOI: 10.1021/jm8006454 BindingDB Entry DOI: 10.7270/Q2S46RT8 |
More data for this Ligand-Target Pair | |