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SMILES: COc1cc2cc(\C=C3/OC(=O)c4c3cc(C)[nH]c4=S)oc2cc1OCc1ccccc1

InChI Key: InChIKey=NGHKSALYCWEJLP-JAIQZWGSSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50274987   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Perforin-1


(Homo sapiens (Human))		BDBM50274987
PNG
((Z)-1-((6-(Benzyloxy)-5-methoxybenzofuran-2-yl)met...)
Show SMILES COc1cc2cc(\C=C3/OC(=O)c4c3cc(C)[nH]c4=S)oc2cc1OCc1ccccc1
Show InChI InChI=1S/C25H19NO5S/c1-14-8-18-20(31-25(27)23(18)24(32)26-14)11-17-9-16-10-21(28-2)22(12-19(16)30-17)29-13-15-6-4-3-5-7-15/h3-12H,13H2,1-2H3,(H,26,32)/b20-11-
NCI pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 5.10E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair