BDBM50275017 (Z)-1-((5-Fluoro-6-methoxy-1H-indol-3-yl)methylene)-6-methyl-4-thioxo-4,5-dihydrofuro[3,4-c]pyridin-3(1H)-one::CHEMBL458835

SMILES: COc1cc2[nH]c(\C=C3/OC(=O)c4c3cc(C)[nH]c4=S)cc2cc1F

InChI Key: InChIKey=UAPBARAEGJAFRW-NSIKDUERSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50275017   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Perforin-1 (Homo sapiens (Human))	BDBM50275017 ((Z)-1-((5-Fluoro-6-methoxy-1H-indol-3-yl)methylene...) Show SMILES COc1cc2[nH]c(\C=C3/OC(=O)c4c3cc(C)[nH]c4=S)cc2cc1F Show InChI InChI=1S/C18H13FN2O3S/c1-8-3-11-14(24-18(22)16(11)17(25)20-8)6-10-4-9-5-12(19)15(23-2)7-13(9)21-10/h3-7,21H,1-2H3,(H,20,25)/b14-6-	NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay				J Med Chem 51: 7614-24 (2009) Article DOI: 10.1021/jm801063n BindingDB Entry DOI: 10.7270/Q24F1QK1
					More data for this Ligand-Target Pair