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SMILES: Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1ccc(s1)-c1ccccc1

InChI Key: InChIKey=JQUJCAMSFSJAHZ-GDNBJRDFSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50275274   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Perforin-1


(Homo sapiens (Human))		BDBM50275274
PNG
((Z)-6-Methyl-1-((5-phenylthiophen-2-yl)methylene)-...)
Show SMILES Cc1cc2\C(OC(=O)c2c(=S)[nH]1)=C\c1ccc(s1)-c1ccccc1
Show InChI InChI=1S/C19H13NO2S2/c1-11-9-14-15(22-19(21)17(14)18(23)20-11)10-13-7-8-16(24-13)12-5-3-2-4-6-12/h2-10H,1H3,(H,20,23)/b15-10-
NCI pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 3.40E+3n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of recombinant perforin (unknown origin)-mediated lysis of human Jurkat T cells by 51Cr release assay

J Med Chem 51: 7614-24 (2009)


Article DOI: 10.1021/jm801063n
BindingDB Entry DOI: 10.7270/Q24F1QK1
More data for this
Ligand-Target Pair