BDBM50275663 4-(5-methyl-7-phenylimidazo[1,5-f][1,2,4]triazin-2-ylamino)benzenesulfonamide::CHEMBL486551

SMILES: Cc1nc(-c2ccccc2)n2nc(Nc3ccc(cc3)S(N)(=O)=O)ncc12

InChI Key: InChIKey=OSGIHOCRIKNRJD-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50275663   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50275663 (4-(5-methyl-7-phenylimidazo[1,5-f][1,2,4]triazin-2...) Show SMILES Cc1nc(-c2ccccc2)n2nc(Nc3ccc(cc3)S(N)(=O)=O)ncc12 Show InChI InChI=1S/C18H16N6O2S/c1-12-16-11-20-18(22-14-7-9-15(10-8-14)27(19,25)26)23-24(16)17(21-12)13-5-3-2-4-6-13/h2-11H,1H3,(H,22,23)(H2,19,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.74E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of PLK1 (unknown origin) expressed in baculovirus infected Trichoplusia ni cells				Bioorg Med Chem Lett 18: 6214-7 (2008) Article DOI: 10.1016/j.bmcl.2008.09.100 BindingDB Entry DOI: 10.7270/Q22Z15DQ
					More data for this Ligand-Target Pair