BDBM50275702 7-(3-bromophenyl)-5-methyl-N-(3,4,5-trimethoxyphenyl)imidazo[1,5-f][1,2,4]triazin-2-amine::CHEMBL519375

SMILES: COc1cc(Nc2ncc3c(C)nc(-c4cccc(Br)c4)n3n2)cc(OC)c1OC

InChI Key: InChIKey=OPHVXMFZPABPCU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50275702   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50275702 (7-(3-bromophenyl)-5-methyl-N-(3,4,5-trimethoxyphen...) Show SMILES COc1cc(Nc2ncc3c(C)nc(-c4cccc(Br)c4)n3n2)cc(OC)c1OC Show InChI InChI=1S/C21H20BrN5O3/c1-12-16-11-23-21(25-15-9-17(28-2)19(30-4)18(10-15)29-3)26-27(16)20(24-12)13-6-5-7-14(22)8-13/h5-11H,1-4H3,(H,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of PLK1 (unknown origin) expressed in baculovirus infected Trichoplusia ni cells				Bioorg Med Chem Lett 18: 6214-7 (2008) Article DOI: 10.1016/j.bmcl.2008.09.100 BindingDB Entry DOI: 10.7270/Q22Z15DQ
					More data for this Ligand-Target Pair