BDBM50275754 (3-(5-methyl-2-(3,4,5-trimethoxyphenylamino)imidazo[1,5-f][1,2,4]triazin-7-yl)phenyl)(phenyl)methanone::CHEMBL519880

SMILES: COc1cc(Nc2ncc3c(C)nc(-c4cccc(c4)C(=O)c4ccccc4)n3n2)cc(OC)c1OC

InChI Key: InChIKey=WCWSPMSEMFFBKI-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50275754   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase PLK1 (Homo sapiens (Human))	BDBM50275754 ((3-(5-methyl-2-(3,4,5-trimethoxyphenylamino)imidaz...) Show SMILES COc1cc(Nc2ncc3c(C)nc(-c4cccc(c4)C(=O)c4ccccc4)n3n2)cc(OC)c1OC Show InChI InChI=1S/C28H25N5O4/c1-17-22-16-29-28(31-21-14-23(35-2)26(37-4)24(15-21)36-3)32-33(22)27(30-17)20-12-8-11-19(13-20)25(34)18-9-6-5-7-10-18/h5-16H,1-4H3,(H,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	410	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of PLK1 (unknown origin) expressed in baculovirus infected Trichoplusia ni cells				Bioorg Med Chem Lett 18: 6214-7 (2008) Article DOI: 10.1016/j.bmcl.2008.09.100 BindingDB Entry DOI: 10.7270/Q22Z15DQ
					More data for this Ligand-Target Pair