BDBM50275974 CHEMBL4126936

SMILES: COc1ccc(Cl)cc1C[C@@H]1CN\C(CN([C@@H](C)C(=O)Nc2cccc(c2)-c2cnn(C)c2)C1=O)=N/N(C)C

InChI Key: InChIKey=DSGGHYFLLSBJAD-GHTZIAJQSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50275974   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Kallikrein 7 (Homo sapiens (Human))	BDBM50275974 (CHEMBL4126936) Show SMILES COc1ccc(Cl)cc1C[C@@H]1CN\C(CN([C@@H](C)C(=O)Nc2cccc(c2)-c2cnn(C)c2)C1=O)=N/N(C)C |r| Show InChI InChI=1S/C28H34ClN7O3/c1-18(27(37)32-24-8-6-7-19(13-24)22-15-31-35(4)16-22)36-17-26(33-34(2)3)30-14-21(28(36)38)11-20-12-23(29)9-10-25(20)39-5/h6-10,12-13,15-16,18,21H,11,14,17H2,1-5H3,(H,30,33)(H,32,37)/t18-,21+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	58	n/a	n/a	n/a	n/a	n/a	n/a
Asubio Pharma Co., Ltd Curated by ChEMBL					Assay Description Inhibition of recombinant human C-terminal His10-tagged KLK7 (E23 to H252 residues) using MOCAcArg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 as su...				Bioorg Med Chem 26: 3639-3653 (2018) Article DOI: 10.1016/j.bmc.2018.05.044 BindingDB Entry DOI: 10.7270/Q27D2XNC
					More data for this Ligand-Target Pair
Kallikrein-7 (Mus musculus)	BDBM50275974 (CHEMBL4126936) Show SMILES COc1ccc(Cl)cc1C[C@@H]1CN\C(CN([C@@H](C)C(=O)Nc2cccc(c2)-c2cnn(C)c2)C1=O)=N/N(C)C |r| Show InChI InChI=1S/C28H34ClN7O3/c1-18(27(37)32-24-8-6-7-19(13-24)22-15-31-35(4)16-22)36-17-26(33-34(2)3)30-14-21(28(36)38)11-20-12-23(29)9-10-25(20)39-5/h6-10,12-13,15-16,18,21H,11,14,17H2,1-5H3,(H,30,33)(H,32,37)/t18-,21+/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Asubio Pharma Co., Ltd Curated by ChEMBL					Assay Description Inhibition of mouse KLK7 using MOCAcArg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 as substrate preincubated for 10 mins followed by substrate addi...				Bioorg Med Chem 26: 3639-3653 (2018) Article DOI: 10.1016/j.bmc.2018.05.044 BindingDB Entry DOI: 10.7270/Q27D2XNC
					More data for this Ligand-Target Pair
Kallikrein 5 (Homo sapiens (Human))	BDBM50275974 (CHEMBL4126936) Show SMILES COc1ccc(Cl)cc1C[C@@H]1CN\C(CN([C@@H](C)C(=O)Nc2cccc(c2)-c2cnn(C)c2)C1=O)=N/N(C)C |r| Show InChI InChI=1S/C28H34ClN7O3/c1-18(27(37)32-24-8-6-7-19(13-24)22-15-31-35(4)16-22)36-17-26(33-34(2)3)30-14-21(28(36)38)11-20-12-23(29)9-10-25(20)39-5/h6-10,12-13,15-16,18,21H,11,14,17H2,1-5H3,(H,30,33)(H,32,37)/t18-,21+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Asubio Pharma Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant human KLK5 using Boc-Val-Pro-Arg-MCA as substrate preincubated for 10 mins followed by substrate addition measured after 30...				Bioorg Med Chem Lett 28: 1371-1375 (2018) Article DOI: 10.1016/j.bmcl.2018.03.011 BindingDB Entry DOI: 10.7270/Q2222XD7
					More data for this Ligand-Target Pair
Trypsin (Homo sapiens (Human))	BDBM50275974 (CHEMBL4126936) Show SMILES COc1ccc(Cl)cc1C[C@@H]1CN\C(CN([C@@H](C)C(=O)Nc2cccc(c2)-c2cnn(C)c2)C1=O)=N/N(C)C |r| Show InChI InChI=1S/C28H34ClN7O3/c1-18(27(37)32-24-8-6-7-19(13-24)22-15-31-35(4)16-22)36-17-26(33-34(2)3)30-14-21(28(36)38)11-20-12-23(29)9-10-25(20)39-5/h6-10,12-13,15-16,18,21H,11,14,17H2,1-5H3,(H,30,33)(H,32,37)/t18-,21+/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Asubio Pharma Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of human trypsin using Boc-Gln-Ala-Arg-MCA as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins by ...				Bioorg Med Chem Lett 28: 1371-1375 (2018) Article DOI: 10.1016/j.bmcl.2018.03.011 BindingDB Entry DOI: 10.7270/Q2222XD7
					More data for this Ligand-Target Pair
Kallikrein 7 (Homo sapiens (Human))	BDBM50275974 (CHEMBL4126936) Show SMILES COc1ccc(Cl)cc1C[C@@H]1CN\C(CN([C@@H](C)C(=O)Nc2cccc(c2)-c2cnn(C)c2)C1=O)=N/N(C)C |r| Show InChI InChI=1S/C28H34ClN7O3/c1-18(27(37)32-24-8-6-7-19(13-24)22-15-31-35(4)16-22)36-17-26(33-34(2)3)30-14-21(28(36)38)11-20-12-23(29)9-10-25(20)39-5/h6-10,12-13,15-16,18,21H,11,14,17H2,1-5H3,(H,30,33)(H,32,37)/t18-,21+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	58	n/a	n/a	n/a	n/a	n/a	n/a
Asubio Pharma Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant human KLK7 using MOCAc-Arg-Pro-Lys-Pro-Val-Glu-Nva-Trp-Arg-Lys(Dnp)-NH2 as substrate preincubated for 10 mins followed by s...				Bioorg Med Chem Lett 28: 1371-1375 (2018) Article DOI: 10.1016/j.bmcl.2018.03.011 BindingDB Entry DOI: 10.7270/Q2222XD7
					More data for this Ligand-Target Pair