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SMILES: CN1Cc2cc(ccc2C1=O)-c1ccc(s1)-c1cncc(NS(=O)(=O)c2ccsc2)c1

InChI Key: InChIKey=RUZJUKWUSKVXNQ-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50276549   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Perforin-1


(Homo sapiens (Human))		BDBM50276549
PNG
(CHEMBL4176055)
Show SMILES CN1Cc2cc(ccc2C1=O)-c1ccc(s1)-c1cncc(NS(=O)(=O)c2ccsc2)c1
Show InChI InChI=1S/C22H17N3O3S3/c1-25-12-16-8-14(2-3-19(16)22(25)26)20-4-5-21(30-20)15-9-17(11-23-10-15)24-31(27,28)18-6-7-29-13-18/h2-11,13,24H,12H2,1H3
NCI pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.25E+4n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of perforin (unknown origin)-mediated 51Cr-labelled human Jurkat cell lysis preincubated with protein for 30 mins followed by cell additio...

Eur J Med Chem 137: 139-155 (2017)


Article DOI: 10.1016/j.ejmech.2017.05.048
BindingDB Entry DOI: 10.7270/Q21R6T15
More data for this
Ligand-Target Pair