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SMILES: CN1Cc2cc(ccc2C1=O)-c1ccc(s1)-c1cncc(NS(=O)(=O)c2scnc2C)c1

InChI Key: InChIKey=ZMXBQJCKAFGAIY-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50276583   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Perforin-1


(Homo sapiens (Human))		BDBM50276583
PNG
(CHEMBL4172227)
Show SMILES CN1Cc2cc(ccc2C1=O)-c1ccc(s1)-c1cncc(NS(=O)(=O)c2scnc2C)c1
Show InChI InChI=1S/C22H18N4O3S3/c1-13-22(30-12-24-13)32(28,29)25-17-8-15(9-23-10-17)20-6-5-19(31-20)14-3-4-18-16(7-14)11-26(2)21(18)27/h3-10,12,25H,11H2,1-2H3
NCI pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 1.16E+4n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of perforin (unknown origin)-mediated 51Cr-labelled human Jurkat cell lysis preincubated with protein for 30 mins followed by cell additio...

Eur J Med Chem 137: 139-155 (2017)


Article DOI: 10.1016/j.ejmech.2017.05.048
BindingDB Entry DOI: 10.7270/Q21R6T15
More data for this
Ligand-Target Pair