BindingDB PrimarySearch

BDBM50276802 4-OHT::AFIMOXIFENE::Afimoxifene::TamoGel

SMILES: CCC(=C(c1ccc(O)cc1)c1ccc(OCCN(C)C)cc1)c1ccccc1

InChI Key: InChIKey=TXUZVZSFRXZGTL-QPLCGJKRSA-N

Data: 4 KI 13 IC50 1 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50276802
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Estrogen receptor (Homo sapiens (Human))	BDBM50276802 (4-OHT \| AFIMOXIFENE \| Afimoxifene \| TamoGel) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents	Article PubMed	0.249	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Le Centre Hospitalier Universitaire de Qu£bec Curated by ChEMBL					Assay Description Inhibition of estradiol binding to estrogen receptor in Human Breast cancer cytosol (3.3% ethanol)				J Med Chem 40: 2117-22 (1997) Article DOI: 10.1021/jm970095o BindingDB Entry DOI: 10.7270/Q2474DKC
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM50276802 (4-OHT \| AFIMOXIFENE \| Afimoxifene \| TamoGel) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents	Article PubMed	0.346	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Le Centre Hospitalier Universitaire de Qu£bec Curated by ChEMBL					Assay Description Apparent inhibition constant for estrogen receptor in Human uterine cytosol in 3.3%ethanol				J Med Chem 40: 2117-22 (1997) Article DOI: 10.1021/jm970095o BindingDB Entry DOI: 10.7270/Q2474DKC
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM50276802 (4-OHT \| AFIMOXIFENE \| Afimoxifene \| TamoGel) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents	Article PubMed	2.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Research & Development Curated by ChEMBL					Assay Description Binding affinity for human estrogen receptor alpha				J Med Chem 48: 2243-7 (2005) Article DOI: 10.1021/jm040154f BindingDB Entry DOI: 10.7270/Q24T6N42
GlaxoSmithKline Research & Development Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM50276802 (4-OHT \| AFIMOXIFENE \| Afimoxifene \| TamoGel) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents	Article PubMed	3.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Research & Development Curated by ChEMBL					Assay Description Binding affinity for human estrogen receptor beta				J Med Chem 48: 2243-7 (2005) Article DOI: 10.1021/jm040154f BindingDB Entry DOI: 10.7270/Q24T6N42
GlaxoSmithKline Research & Development Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM50276802 (4-OHT \| AFIMOXIFENE \| Afimoxifene \| TamoGel) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Trinity College Curated by ChEMBL					Assay Description Antagonist activity at estrogen receptor alpha/beta in human Ishikawa cells after 72 hrs by alkaline phosphatase assay				J Med Chem 61: 514-534 (2018) Article DOI: 10.1021/acs.jmedchem.6b01917 BindingDB Entry DOI: 10.7270/Q20K2C6G
Trinity College Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM50276802 (4-OHT \| AFIMOXIFENE \| Afimoxifene \| TamoGel) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
Trinity College Curated by ChEMBL					Assay Description Displacement of fluorescein-labeled estradiol (fluoromone) from human recombinant full-length estrogen receptor beta after 2 hrs by fluorescence pola...				J Med Chem 61: 514-534 (2018) Article DOI: 10.1021/acs.jmedchem.6b01917 BindingDB Entry DOI: 10.7270/Q20K2C6G
Trinity College Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM50276802 (4-OHT \| AFIMOXIFENE \| Afimoxifene \| TamoGel) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
Trinity College Curated by ChEMBL					Assay Description Displacement of fluorescein-labeled estradiol (fluoromone) from human recombinant full-length estrogen receptor alpha after 2 hrs by fluorescence pol...				J Med Chem 61: 514-534 (2018) Article DOI: 10.1021/acs.jmedchem.6b01917 BindingDB Entry DOI: 10.7270/Q20K2C6G
Trinity College Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM50276802 (4-OHT \| AFIMOXIFENE \| Afimoxifene \| TamoGel) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Antagonism of estrogen action in a mammary tumor cell line was assayed via inhibition of MCF-7 cell proliferation stimulated by 10 e-11 M 17-beta-est...				J Med Chem 40: 146-67 (1997) Article DOI: 10.1021/jm9606352 BindingDB Entry DOI: 10.7270/Q2PZ5CKJ
Eli Lilly and Company Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM50276802 (4-OHT \| AFIMOXIFENE \| Afimoxifene \| TamoGel) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Versailles/St. Quentin-en-Yvelines Curated by ChEMBL					Assay Description Anti-estrogenicity for 50% inhibition of the MVLN cell luciferase activity due to 0.1 nM E2 (estradiol)				J Med Chem 40: 1104-11 (1997) Article DOI: 10.1021/jm950624t BindingDB Entry DOI: 10.7270/Q218397P
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM50276802 (4-OHT \| AFIMOXIFENE \| Afimoxifene \| TamoGel) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Free University of Berlin Curated by ChEMBL					Assay Description Inhibition of estradiol induced estrogen receptor transcriptional activation in MCF-7-2a cells				J Med Chem 46: 1484-91 (2003) Article DOI: 10.1021/jm0210562 BindingDB Entry DOI: 10.7270/Q28W3H29
Free University of Berlin Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM50276802 (4-OHT \| AFIMOXIFENE \| Afimoxifene \| TamoGel) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	510	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Antagonist activity as inhibition of 1 nM 17-beta-estradiol stimulated alkaline phosphatase induction in Ishikawa endometrial cells				Bioorg Med Chem Lett 14: 5103-6 (2004) Article DOI: 10.1016/j.bmcl.2004.07.072 BindingDB Entry DOI: 10.7270/Q25X2CQ6
Eli Lilly and Company Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM50276802 (4-OHT \| AFIMOXIFENE \| Afimoxifene \| TamoGel) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	0.800	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Agonist activity as alkaline phosphatase induction in Ishikawa endometrial cells compared to E2				Bioorg Med Chem Lett 14: 5103-6 (2004) Article DOI: 10.1016/j.bmcl.2004.07.072 BindingDB Entry DOI: 10.7270/Q25X2CQ6
Eli Lilly and Company Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM50276802 (4-OHT \| AFIMOXIFENE \| Afimoxifene \| TamoGel) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Antagonist effect against 10 pM 17-beta-estradiol induced MCF-7 cell proliferation				Bioorg Med Chem Lett 14: 5103-6 (2004) Article DOI: 10.1016/j.bmcl.2004.07.072 BindingDB Entry DOI: 10.7270/Q25X2CQ6
Eli Lilly and Company Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM50276802 (4-OHT \| AFIMOXIFENE \| Afimoxifene \| TamoGel) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
McGill University Curated by ChEMBL					Assay Description Antagonist activity at recombinant human ERalpha expressed in HEK293 cells assessed as inhibition of estradiol-induced YFP-fused SRC1 coactivator rec...				Bioorg Med Chem 26: 4428-4440 (2018) Article DOI: 10.1016/j.bmc.2018.07.026 BindingDB Entry DOI: 10.7270/Q26W9DQ7
McGill University Curated by ChEMBL					More data for this Ligand-Target Pair
Steroid hormone receptor ERR2 (Homo sapiens (Human))	BDBM50276802 (4-OHT \| AFIMOXIFENE \| Afimoxifene \| TamoGel) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	886	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research and Development LLC Curated by ChEMBL					Assay Description Antagonist activity at recombinant GST-tagged human ERRbeta LBD assessed as inhibition of fluorescein-labeled coactivator peptide recruitment preincu...				Eur J Med Chem 138: 830-853 (2017) Article DOI: 10.1016/j.ejmech.2017.07.015 BindingDB Entry DOI: 10.7270/Q2W098F7
Janssen Research and Development LLC Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM50276802 (4-OHT \| AFIMOXIFENE \| Afimoxifene \| TamoGel) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Research & Development Curated by ChEMBL					Assay Description pIC50 for 1 nM estradiol-induced Ishikawa cell proliferation				J Med Chem 48: 2243-7 (2005) Article DOI: 10.1021/jm040154f BindingDB Entry DOI: 10.7270/Q24T6N42
GlaxoSmithKline Research & Development Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen-related receptor gamma (Homo sapiens (Human))	BDBM50276802 (4-OHT \| AFIMOXIFENE \| Afimoxifene \| TamoGel) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research and Development LLC Curated by ChEMBL					Assay Description Antagonist activity at ERRgamma (unknown origin) assessed as inhibition of co-activator peptide recruitment by TR-FRET assay				Eur J Med Chem 138: 830-853 (2017) Article DOI: 10.1016/j.ejmech.2017.07.015 BindingDB Entry DOI: 10.7270/Q2W098F7
Janssen Research and Development LLC Curated by ChEMBL					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM50276802 (4-OHT \| AFIMOXIFENE \| Afimoxifene \| TamoGel) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Research and Development LLC Curated by ChEMBL					Assay Description Inhibition of fluormone ES2 green binding to recombinant full length human ERalpha expressed in insect cells by fluorescence polarization assay				Eur J Med Chem 138: 830-853 (2017) Article DOI: 10.1016/j.ejmech.2017.07.015 BindingDB Entry DOI: 10.7270/Q2W098F7
Janssen Research and Development LLC Curated by ChEMBL					More data for this Ligand-Target Pair