Found 5 hits for monomerid = 50277363 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50277363
(CHEMBL475510 | N-(3-tert-butylphenyl)-4-(pyridin-4...)Show InChI InChI=1S/C20H22N4OS/c1-20(2,3)15-5-4-6-16(11-15)23-19(25)18-17(13-26-24-18)22-12-14-7-9-21-10-8-14/h4-11,13,22H,12H2,1-3H3,(H,23,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE
Curated by ChEMBL
| Assay Description Inhibition of VEGFR2 (unknown origin) at IC90 concentration by ATP based competition assay |
Bioorg Med Chem Lett 19: 1195-8 (2009)
Article DOI: 10.1016/j.bmcl.2008.12.078 BindingDB Entry DOI: 10.7270/Q2W66KNK |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50277363
(CHEMBL475510 | N-(3-tert-butylphenyl)-4-(pyridin-4...)Show InChI InChI=1S/C20H22N4OS/c1-20(2,3)15-5-4-6-16(11-15)23-19(25)18-17(13-26-24-18)22-12-14-7-9-21-10-8-14/h4-11,13,22H,12H2,1-3H3,(H,23,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE
Curated by ChEMBL
| Assay Description Inhibition of VEGFR2 (unknown origin) at IC50 concentration by ATP based competition assay |
Bioorg Med Chem Lett 19: 1195-8 (2009)
Article DOI: 10.1016/j.bmcl.2008.12.078 BindingDB Entry DOI: 10.7270/Q2W66KNK |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50277363
(CHEMBL475510 | N-(3-tert-butylphenyl)-4-(pyridin-4...)Show InChI InChI=1S/C20H22N4OS/c1-20(2,3)15-5-4-6-16(11-15)23-19(25)18-17(13-26-24-18)22-12-14-7-9-21-10-8-14/h4-11,13,22H,12H2,1-3H3,(H,23,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE
Curated by ChEMBL
| Assay Description Inhibition of VEGFR2 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay |
Bioorg Med Chem Lett 19: 1195-8 (2009)
Article DOI: 10.1016/j.bmcl.2008.12.078 BindingDB Entry DOI: 10.7270/Q2W66KNK |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 1
(Homo sapiens (Human)) | BDBM50277363
(CHEMBL475510 | N-(3-tert-butylphenyl)-4-(pyridin-4...)Show InChI InChI=1S/C20H22N4OS/c1-20(2,3)15-5-4-6-16(11-15)23-19(25)18-17(13-26-24-18)22-12-14-7-9-21-10-8-14/h4-11,13,22H,12H2,1-3H3,(H,23,25) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE
Curated by ChEMBL
| Assay Description Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assay |
Bioorg Med Chem Lett 19: 1195-8 (2009)
Article DOI: 10.1016/j.bmcl.2008.12.078 BindingDB Entry DOI: 10.7270/Q2W66KNK |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50277363
(CHEMBL475510 | N-(3-tert-butylphenyl)-4-(pyridin-4...)Show InChI InChI=1S/C20H22N4OS/c1-20(2,3)15-5-4-6-16(11-15)23-19(25)18-17(13-26-24-18)22-12-14-7-9-21-10-8-14/h4-11,13,22H,12H2,1-3H3,(H,23,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 82 | n/a | n/a | n/a | n/a | n/a | n/a |
deCODE
Curated by ChEMBL
| Assay Description Inhibition of VEGFR2 (unknown origin) expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISA |
Bioorg Med Chem Lett 19: 1195-8 (2009)
Article DOI: 10.1016/j.bmcl.2008.12.078 BindingDB Entry DOI: 10.7270/Q2W66KNK |
More data for this Ligand-Target Pair | |