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BDBM50277815 3-methoxy-N-((S)-3-methoxy-1-((S)-3-methoxy-1-((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-ylamino)-1-oxopropan-2-ylamino)-1-oxopropan-2-yl)isoxazole-5-carboxamide::CHEMBL483738

SMILES: COC[C@H](NC(=O)[C@H](COC)NC(=O)c1cc(OC)no1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1

InChI Key: InChIKey=FXLGKDDPGGUZMS-GVRJUGSUSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50277815   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
26S proteosome


(Homo sapiens (Human))		BDBM50277815
PNG
(3-methoxy-N-((S)-3-methoxy-1-((S)-3-methoxy-1-((S)...)
Show SMILES COC[C@H](NC(=O)[C@H](COC)NC(=O)c1cc(OC)no1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |r|
Show InChI InChI=1S/C22H34N4O9/c1-12(2)7-13(18(27)22(3)11-34-22)23-19(28)14(9-31-4)24-20(29)15(10-32-5)25-21(30)16-8-17(33-6)26-35-16/h8,12-15H,7,9-11H2,1-6H3,(H,23,28)(H,24,29)(H,25,30)/t13-,14-,15-,22+/m0/s1
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n/an/a 22n/an/an/an/an/an/a



Proteolix, Inc.

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of LMP7 immunoproteasome by proteasome active site ELISA

J Med Chem 52: 3028-38 (2009)


Article DOI: 10.1021/jm801329v
BindingDB Entry DOI: 10.7270/Q2ZW1KS0
More data for this
Ligand-Target Pair