BDBM50278538 4-(7-(m-tolylamino)thiazolo[4,5-d]pyrimidin-2-ylamino)benzenesulfonamide::CHEMBL513362

SMILES: Cc1cccc(Nc2ncnc3nc(Nc4ccc(cc4)S(N)(=O)=O)sc23)c1

InChI Key: InChIKey=DKCJHJKLYAZBHE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50278538   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50278538 (4-(7-(m-tolylamino)thiazolo[4,5-d]pyrimidin-2-ylam...) Show SMILES Cc1cccc(Nc2ncnc3nc(Nc4ccc(cc4)S(N)(=O)=O)sc23)c1 Show InChI InChI=1S/C18H16N6O2S2/c1-11-3-2-4-13(9-11)22-16-15-17(21-10-20-16)24-18(27-15)23-12-5-7-14(8-6-12)28(19,25)26/h2-10H,1H3,(H2,19,25,26)(H2,20,21,22,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development LLC Curated by ChEMBL					Assay Description Inhibition of EGFR (unknown origin)				Bioorg Med Chem Lett 19: 2333-7 (2009) Article DOI: 10.1016/j.bmcl.2009.02.067 BindingDB Entry DOI: 10.7270/Q23X86H3
					More data for this Ligand-Target Pair