null

SMILES: CNc1ncc(cn1)C#Cc1ccccc1

InChI Key: InChIKey=QYULUNXYZOOROK-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50278924   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 1 (Homo sapiens (Human))	BDBM50278924 (CHEMBL505105 | N-methyl-5-(phenylethynyl)pyrimidin...) Show SMILES CNc1ncc(cn1)C#Cc1ccccc1 Show InChI InChI=1S/C13H11N3/c1-14-13-15-9-12(10-16-13)8-7-11-5-3-2-4-6-11/h2-6,9-10H,1H3,(H,14,15,16)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at mGlu1 receptor				J Med Chem 52: 4103-6 (2009) Article DOI: 10.1021/jm900654c BindingDB Entry DOI: 10.7270/Q2PZ58RJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat))	BDBM50278924 (CHEMBL505105 | N-methyl-5-(phenylethynyl)pyrimidin...) Show SMILES CNc1ncc(cn1)C#Cc1ccccc1 Show InChI InChI=1S/C13H11N3/c1-14-13-15-9-12(10-16-13)8-7-11-5-3-2-4-6-11/h2-6,9-10H,1H3,(H,14,15,16)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.43E+4	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulator activity at rat mGlu5 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced response relativ...				J Med Chem 52: 4103-6 (2009) Article DOI: 10.1021/jm900654c BindingDB Entry DOI: 10.7270/Q2PZ58RJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50278924 (CHEMBL505105 | N-methyl-5-(phenylethynyl)pyrimidin...) Show SMILES CNc1ncc(cn1)C#Cc1ccccc1 Show InChI InChI=1S/C13H11N3/c1-14-13-15-9-12(10-16-13)8-7-11-5-3-2-4-6-11/h2-6,9-10H,1H3,(H,14,15,16)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at mGlu2 receptor				J Med Chem 52: 4103-6 (2009) Article DOI: 10.1021/jm900654c BindingDB Entry DOI: 10.7270/Q2PZ58RJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50278924 (CHEMBL505105 | N-methyl-5-(phenylethynyl)pyrimidin...) Show SMILES CNc1ncc(cn1)C#Cc1ccccc1 Show InChI InChI=1S/C13H11N3/c1-14-13-15-9-12(10-16-13)8-7-11-5-3-2-4-6-11/h2-6,9-10H,1H3,(H,14,15,16)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at mGlu3 receptor				J Med Chem 52: 4103-6 (2009) Article DOI: 10.1021/jm900654c BindingDB Entry DOI: 10.7270/Q2PZ58RJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50278924 (CHEMBL505105 | N-methyl-5-(phenylethynyl)pyrimidin...) Show SMILES CNc1ncc(cn1)C#Cc1ccccc1 Show InChI InChI=1S/C13H11N3/c1-14-13-15-9-12(10-16-13)8-7-11-5-3-2-4-6-11/h2-6,9-10H,1H3,(H,14,15,16)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Positive allosteric modulation activity at mGlu5 receptor				J Med Chem 55: 1445-64 (2012) Article DOI: 10.1021/jm201139r BindingDB Entry DOI: 10.7270/Q25D8SWH
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 7 (Homo sapiens (Human))	BDBM50278924 (CHEMBL505105 | N-methyl-5-(phenylethynyl)pyrimidin...) Show SMILES CNc1ncc(cn1)C#Cc1ccccc1 Show InChI InChI=1S/C13H11N3/c1-14-13-15-9-12(10-16-13)8-7-11-5-3-2-4-6-11/h2-6,9-10H,1H3,(H,14,15,16)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at mGlu7 receptor				J Med Chem 52: 4103-6 (2009) Article DOI: 10.1021/jm900654c BindingDB Entry DOI: 10.7270/Q2PZ58RJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 8 (Homo sapiens (Human))	BDBM50278924 (CHEMBL505105 | N-methyl-5-(phenylethynyl)pyrimidin...) Show SMILES CNc1ncc(cn1)C#Cc1ccccc1 Show InChI InChI=1S/C13H11N3/c1-14-13-15-9-12(10-16-13)8-7-11-5-3-2-4-6-11/h2-6,9-10H,1H3,(H,14,15,16)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at mGlu8 receptor				J Med Chem 52: 4103-6 (2009) Article DOI: 10.1021/jm900654c BindingDB Entry DOI: 10.7270/Q2PZ58RJ
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 5 (Homo sapiens (Human))	BDBM50278924 (CHEMBL505105 | N-methyl-5-(phenylethynyl)pyrimidin...) Show SMILES CNc1ncc(cn1)C#Cc1ccccc1 Show InChI InChI=1S/C13H11N3/c1-14-13-15-9-12(10-16-13)8-7-11-5-3-2-4-6-11/h2-6,9-10H,1H3,(H,14,15,16)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	30.7	n/a	n/a	n/a	n/a
AstraZeneca Pharmaceuticals Curated by ChEMBL					Assay Description Positive allosteric modulation of human mGlu4 receptor expressed in human HEK293 cells assessed as potentiation of glutamate-induced calcium mobiliza...				Bioorg Med Chem Lett 21: 1402-6 (2011) Article DOI: 10.1016/j.bmcl.2011.01.027 BindingDB Entry DOI: 10.7270/Q2Q81DC5
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 4 (Homo sapiens (Human))	BDBM50278924 (CHEMBL505105 | N-methyl-5-(phenylethynyl)pyrimidin...) Show SMILES CNc1ncc(cn1)C#Cc1ccccc1 Show InChI InChI=1S/C13H11N3/c1-14-13-15-9-12(10-16-13)8-7-11-5-3-2-4-6-11/h2-6,9-10H,1H3,(H,14,15,16)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vanderbilt University Medical Center Curated by ChEMBL					Assay Description Antagonist activity at mGlu4 receptor				J Med Chem 52: 4103-6 (2009) Article DOI: 10.1021/jm900654c BindingDB Entry DOI: 10.7270/Q2PZ58RJ
					More data for this Ligand-Target Pair