BDBM50279163 CHEMBL1203981::CHEMBL496861
SMILES: CN(C)C(=O)c1ccc2C(C(=Nc3ccc(CN4CCCCC4)cc3)c3ccccc3)C(=O)Nc2c1
InChI Key: InChIKey=TVJQCMWECHMREF-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50279163 (CHEMBL1203981 | CHEMBL496861) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 246 | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH& Co KG Curated by ChEMBL | Assay Description Inhibition of TGFbeta receptor in human HaCaT cells assessed as Smad phosphorylation by ELISA | J Med Chem 53: 7287-95 (2010) Article DOI: 10.1021/jm100812a BindingDB Entry DOI: 10.7270/Q2F47PCW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM50279163 (CHEMBL1203981 | CHEMBL496861) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.31E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH&Co KG Curated by ChEMBL | Assay Description Inhibition of human VEGFR2 expressed in Sf9 cells | J Med Chem 52: 4466-80 (2009) Article DOI: 10.1021/jm900431g BindingDB Entry DOI: 10.7270/Q2RB75JS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TGF-beta receptor type-1 (Homo sapiens (Human)) | BDBM50279163 (CHEMBL1203981 | CHEMBL496861) | PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharma GmbH& Co KG Curated by ChEMBL | Assay Description Inhibition of TGFbeta receptor | J Med Chem 53: 7287-95 (2010) Article DOI: 10.1021/jm100812a BindingDB Entry DOI: 10.7270/Q2F47PCW | |||||||||||
More data for this Ligand-Target Pair |