BDBM50279591 CHEMBL4172155

SMILES: COC(=O)c1ccc2\C(=C(\Nc3ccc4CCN(C(=O)Cn5cncn5)c4c3)c3ccccc3)C(=O)Nc2c1

InChI Key: InChIKey=PAPPXQDTTZPULX-RQZHXJHFSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50279591   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50279591 (CHEMBL4172155) Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc4CCN(C(=O)Cn5cncn5)c4c3)c3ccccc3)C(=O)Nc2c1 Show InChI InChI=1S/C29H24N6O4/c1-39-29(38)20-8-10-22-23(13-20)33-28(37)26(22)27(19-5-3-2-4-6-19)32-21-9-7-18-11-12-35(24(18)14-21)25(36)15-34-17-30-16-31-34/h2-10,13-14,16-17,32H,11-12,15H2,1H3,(H,33,37)/b27-26-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Shenyang Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of dihydrofolate reductase in Lactobacillus casei				ACS Med Chem Lett 8: 1142-1147 (2017) Article DOI: 10.1021/acsmedchemlett.7b00164 BindingDB Entry DOI: 10.7270/Q2TM7DND
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Mus musculus (mouse))	BDBM50279591 (CHEMBL4172155) Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc4CCN(C(=O)Cn5cncn5)c4c3)c3ccccc3)C(=O)Nc2c1 Show InChI InChI=1S/C29H24N6O4/c1-39-29(38)20-8-10-22-23(13-20)33-28(37)26(22)27(19-5-3-2-4-6-19)32-21-9-7-18-11-12-35(24(18)14-21)25(36)15-34-17-30-16-31-34/h2-10,13-14,16-17,32H,11-12,15H2,1H3,(H,33,37)/b27-26-	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Shenyang Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of PDGFR in mouse NIH/3T3 cells assessed as reduction in recombinant human PDGF-BB-induced cell proliferation after 42 hrs by cell titer 9...				ACS Med Chem Lett 8: 1142-1147 (2017) Article DOI: 10.1021/acsmedchemlett.7b00164 BindingDB Entry DOI: 10.7270/Q2TM7DND
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50279591 (CHEMBL4172155) Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc4CCN(C(=O)Cn5cncn5)c4c3)c3ccccc3)C(=O)Nc2c1 Show InChI InChI=1S/C29H24N6O4/c1-39-29(38)20-8-10-22-23(13-20)33-28(37)26(22)27(19-5-3-2-4-6-19)32-21-9-7-18-11-12-35(24(18)14-21)25(36)15-34-17-30-16-31-34/h2-10,13-14,16-17,32H,11-12,15H2,1H3,(H,33,37)/b27-26-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Shenyang Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant VEGFR2 (unknown origin) by off-chip mobility shift assay				ACS Med Chem Lett 8: 1142-1147 (2017) Article DOI: 10.1021/acsmedchemlett.7b00164 BindingDB Entry DOI: 10.7270/Q2TM7DND
					More data for this Ligand-Target Pair
1,3-beta-glucan synthase component GLS2 (Saccharomyces cerevisiae)	BDBM50279591 (CHEMBL4172155) Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc4CCN(C(=O)Cn5cncn5)c4c3)c3ccccc3)C(=O)Nc2c1 Show InChI InChI=1S/C29H24N6O4/c1-39-29(38)20-8-10-22-23(13-20)33-28(37)26(22)27(19-5-3-2-4-6-19)32-21-9-7-18-11-12-35(24(18)14-21)25(36)15-34-17-30-16-31-34/h2-10,13-14,16-17,32H,11-12,15H2,1H3,(H,33,37)/b27-26-	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>30	n/a	n/a	n/a	n/a	n/a	n/a
Shenyang Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human ERG				ACS Med Chem Lett 8: 1142-1147 (2017) Article DOI: 10.1021/acsmedchemlett.7b00164 BindingDB Entry DOI: 10.7270/Q2TM7DND
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM50279591 (CHEMBL4172155) Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc4CCN(C(=O)Cn5cncn5)c4c3)c3ccccc3)C(=O)Nc2c1 Show InChI InChI=1S/C29H24N6O4/c1-39-29(38)20-8-10-22-23(13-20)33-28(37)26(22)27(19-5-3-2-4-6-19)32-21-9-7-18-11-12-35(24(18)14-21)25(36)15-34-17-30-16-31-34/h2-10,13-14,16-17,32H,11-12,15H2,1H3,(H,33,37)/b27-26-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	620	n/a	n/a	n/a	n/a	n/a	n/a
Shenyang Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of recombinant FGFR1 (unknown origin) by off-chip mobility shift assay				ACS Med Chem Lett 8: 1142-1147 (2017) Article DOI: 10.1021/acsmedchemlett.7b00164 BindingDB Entry DOI: 10.7270/Q2TM7DND
					More data for this Ligand-Target Pair