BDBM50279592 CHEMBL4166187

SMILES: COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N3CCC(CN4CCN(C)CC4)C3=O)c3ccccc3)C(=O)Nc2c1

InChI Key: InChIKey=VPZDWQHUUTZTSQ-FLWNBWAVSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50279592   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM50279592 (CHEMBL4166187) Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N3CCC(CN4CCN(C)CC4)C3=O)c3ccccc3)C(=O)Nc2c1 Show InChI InChI=1S/C33H35N5O4/c1-36-16-18-37(19-17-36)21-24-14-15-38(32(24)40)26-11-9-25(10-12-26)34-30(22-6-4-3-5-7-22)29-27-13-8-23(33(41)42-2)20-28(27)35-31(29)39/h3-13,20,24,34H,14-19,21H2,1-2H3,(H,35,39)/b30-29-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Shenyang Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of dihydrofolate reductase in HeLa cells				ACS Med Chem Lett 8: 1142-1147 (2017) Article DOI: 10.1021/acsmedchemlett.7b00164 BindingDB Entry DOI: 10.7270/Q2TM7DND
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50279592 (CHEMBL4166187) Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N3CCC(CN4CCN(C)CC4)C3=O)c3ccccc3)C(=O)Nc2c1 Show InChI InChI=1S/C33H35N5O4/c1-36-16-18-37(19-17-36)21-24-14-15-38(32(24)40)26-11-9-25(10-12-26)34-30(22-6-4-3-5-7-22)29-27-13-8-23(33(41)42-2)20-28(27)35-31(29)39/h3-13,20,24,34H,14-19,21H2,1-2H3,(H,35,39)/b30-29-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Shenyang Pharmaceutical University Curated by ChEMBL					Assay Description -Log (Ki) value for butyrylcholinesterase by inhibiting DFP				ACS Med Chem Lett 8: 1142-1147 (2017) Article DOI: 10.1021/acsmedchemlett.7b00164 BindingDB Entry DOI: 10.7270/Q2TM7DND
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Mus musculus (mouse))	BDBM50279592 (CHEMBL4166187) Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N3CCC(CN4CCN(C)CC4)C3=O)c3ccccc3)C(=O)Nc2c1 Show InChI InChI=1S/C33H35N5O4/c1-36-16-18-37(19-17-36)21-24-14-15-38(32(24)40)26-11-9-25(10-12-26)34-30(22-6-4-3-5-7-22)29-27-13-8-23(33(41)42-2)20-28(27)35-31(29)39/h3-13,20,24,34H,14-19,21H2,1-2H3,(H,35,39)/b30-29-	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Shenyang Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of PDGFR in mouse NIH/3T3 cells assessed as reduction in recombinant human PDGF-BB-induced cell proliferation after 42 hrs by cell titer 9...				ACS Med Chem Lett 8: 1142-1147 (2017) Article DOI: 10.1021/acsmedchemlett.7b00164 BindingDB Entry DOI: 10.7270/Q2TM7DND
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50279592 (CHEMBL4166187) Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N3CCC(CN4CCN(C)CC4)C3=O)c3ccccc3)C(=O)Nc2c1 Show InChI InChI=1S/C33H35N5O4/c1-36-16-18-37(19-17-36)21-24-14-15-38(32(24)40)26-11-9-25(10-12-26)34-30(22-6-4-3-5-7-22)29-27-13-8-23(33(41)42-2)20-28(27)35-31(29)39/h3-13,20,24,34H,14-19,21H2,1-2H3,(H,35,39)/b30-29-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
Shenyang Pharmaceutical University Curated by ChEMBL					Assay Description H1-antihistamine activity on guinea pig ileum				ACS Med Chem Lett 8: 1142-1147 (2017) Article DOI: 10.1021/acsmedchemlett.7b00164 BindingDB Entry DOI: 10.7270/Q2TM7DND
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Mus musculus (mouse))	BDBM50279592 (CHEMBL4166187) Show SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N3CCC(CN4CCN(C)CC4)C3=O)c3ccccc3)C(=O)Nc2c1 Show InChI InChI=1S/C33H35N5O4/c1-36-16-18-37(19-17-36)21-24-14-15-38(32(24)40)26-11-9-25(10-12-26)34-30(22-6-4-3-5-7-22)29-27-13-8-23(33(41)42-2)20-28(27)35-31(29)39/h3-13,20,24,34H,14-19,21H2,1-2H3,(H,35,39)/b30-29-	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Shenyang Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of PDGFR in mouse NIH/3T3 cells assessed as reduction in recombinant human PDGF-BB-induced cell proliferation after 42 hrs by cell titer 9...				ACS Med Chem Lett 8: 1142-1147 (2017) Article DOI: 10.1021/acsmedchemlett.7b00164 BindingDB Entry DOI: 10.7270/Q2TM7DND
					More data for this Ligand-Target Pair