BDBM50280061 CHEMBL8633::Sodium; (E)-8-(3,6-difluoro-fluoren-9-ylidene)-3,5-dihydroxy-8-(1-methyl-1H-tetrazol-5-yl)-oct-6-enoate

SMILES: [#6]-n1nnnc1\[#6](\[#6]=[#6]\[#6](-[#8])-[#6]-[#6](-[#8])-[#6]-[#6](-[#8-])=O)=[#6]-1/c2ccc(F)cc2-c2cc(F)ccc-12

InChI Key: InChIKey=FKJZGUOTNGCEHQ-QPJJXVBHSA-M

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50280061   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
HMG-CoA reductase (Rattus norvegicus (rat))	BDBM50280061 (CHEMBL8633 | Sodium; (E)-8-(3,6-difluoro-fluoren-9...) Show SMILES [#6]-n1nnnc1\[#6](\[#6]=[#6]\[#6](-[#8])-[#6]-[#6](-[#8])-[#6]-[#6](-[#8-])=O)=[#6]-1/c2ccc(F)cc2-c2cc(F)ccc-12 Show InChI InChI=1S/C23H20F2N4O4/c1-29-23(26-27-28-29)18(7-4-14(30)10-15(31)11-21(32)33)22-16-5-2-12(24)8-19(16)20-9-13(25)3-6-17(20)22/h2-9,14-15,30-31H,10-11H2,1H3,(H,32,33)/p-1/b7-4+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article	n/a	n/a	>4.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for its inhibitory activity against rat liver microsomal HMG-CoA reductase				Bioorg Med Chem Lett 2: 99-104 (1992) Article DOI: 10.1016/S0960-894X(00)80665-4 BindingDB Entry DOI: 10.7270/Q2X92B57
					More data for this Ligand-Target Pair