BDBM50280813 5-[(1S,2S)-1-Hydroxy-2-(4-phenyl-piperidin-1-yl)-propyl]-1,3-dihydro-indol-2-one::CHEMBL366809

SMILES: C[C@@H]([C@@H](O)c1ccc2NC(=O)Cc2c1)N1CCC(CC1)c1ccccc1

InChI Key: InChIKey=HJRGLUUTXXPQKZ-OYHNWAKOSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50280813   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50280813 (5-[(1S,2S)-1-Hydroxy-2-(4-phenyl-piperidin-1-yl)-p...) Show SMILES C[C@@H]([C@@H](O)c1ccc2NC(=O)Cc2c1)N1CCC(CC1)c1ccccc1 Show InChI InChI=1S/C22H26N2O2/c1-15(22(26)18-7-8-20-19(13-18)14-21(25)23-20)24-11-9-17(10-12-24)16-5-3-2-4-6-16/h2-8,13,15,17,22,26H,9-12,14H2,1H3,(H,23,25)/t15-,22+/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	349	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Tested for the Alpha-1 adrenergic receptor affinity in a standard radioligand binding assay with [3H]- prazosin				Bioorg Med Chem Lett 3: 91-94 (1993) Article DOI: 10.1016/S0960-894X(00)80098-0 BindingDB Entry DOI: 10.7270/Q2GT5N4S
					More data for this Ligand-Target Pair
NMDA receptor subunit 2C (GluN2C) (Rattus norvegicus (Rat))	BDBM50280813 (5-[(1S,2S)-1-Hydroxy-2-(4-phenyl-piperidin-1-yl)-p...) Show SMILES C[C@@H]([C@@H](O)c1ccc2NC(=O)Cc2c1)N1CCC(CC1)c1ccccc1 Show InChI InChI=1S/C22H26N2O2/c1-15(22(26)18-7-8-20-19(13-18)14-21(25)23-20)24-11-9-17(10-12-24)16-5-3-2-4-6-16/h2-8,13,15,17,22,26H,9-12,14H2,1H3,(H,23,25)/t15-,22+/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Tested for the NMDA antagonist activity using a functional assay, by protection of cultured hippocampus neurons from the toxic effects of extracellul...				Bioorg Med Chem Lett 3: 91-94 (1993) Article DOI: 10.1016/S0960-894X(00)80098-0 BindingDB Entry DOI: 10.7270/Q2GT5N4S
					More data for this Ligand-Target Pair