Found 13 hits for monomerid = 50280934 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50280934
(1-tert-Butylamino-3-(thiochroman-8-yloxy)-propan-2...)Show InChI InChI=1S/C16H25NO2S/c1-16(2,3)17-10-13(18)11-19-14-8-4-6-12-7-5-9-20-15(12)14/h4,6,8,13,17-18H,5,7,9-11H2,1-3H3 | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
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| 6.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recherches Servier
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 280: 1241-9 (1997)
BindingDB Entry DOI: 10.7270/Q2CJ8C04 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat)) | BDBM50280934
(1-tert-Butylamino-3-(thiochroman-8-yloxy)-propan-2...)Show InChI InChI=1S/C16H25NO2S/c1-16(2,3)17-10-13(18)11-19-14-8-4-6-12-7-5-9-20-15(12)14/h4,6,8,13,17-18H,5,7,9-11H2,1-3H3 | PDB
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| 7.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Displacement of [3H]-8-OH-DPAT from rat hippocampal 5-hydroxytryptamine 1A receptor |
Bioorg Med Chem Lett 3: 2035-2038 (1993)
Article DOI: 10.1016/S0960-894X(01)81009-X BindingDB Entry DOI: 10.7270/Q2XW4JQH |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat)) | BDBM50280934
(1-tert-Butylamino-3-(thiochroman-8-yloxy)-propan-2...)Show InChI InChI=1S/C16H25NO2S/c1-16(2,3)17-10-13(18)11-19-14-8-4-6-12-7-5-9-20-15(12)14/h4,6,8,13,17-18H,5,7,9-11H2,1-3H3 | PDB
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| Article PubMed
| 8.31 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recherches Servier
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 268: 337-52 (1994)
Article DOI: 10.1016/j.bioorg.2015.06.004 BindingDB Entry DOI: 10.7270/Q2H130HG |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50280934
(1-tert-Butylamino-3-(thiochroman-8-yloxy)-propan-2...)Show InChI InChI=1S/C16H25NO2S/c1-16(2,3)17-10-13(18)11-19-14-8-4-6-12-7-5-9-20-15(12)14/h4,6,8,13,17-18H,5,7,9-11H2,1-3H3 | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
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| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
INSERM U.288
Curated by PDSP Ki Database
| |
Neuropsychopharmacology 3: 349-60 (1990)
BindingDB Entry DOI: 10.7270/Q2N29VFS |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat)) | BDBM50280934
(1-tert-Butylamino-3-(thiochroman-8-yloxy)-propan-2...)Show InChI InChI=1S/C16H25NO2S/c1-16(2,3)17-10-13(18)11-19-14-8-4-6-12-7-5-9-20-15(12)14/h4,6,8,13,17-18H,5,7,9-11H2,1-3H3 | PDB
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| 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Displacement of [3H]-8-OH-DPAT from rat hippocampal 5-hydroxytryptamine 1A receptor |
Bioorg Med Chem Lett 3: 2035-2038 (1993)
Article DOI: 10.1016/S0960-894X(01)81009-X BindingDB Entry DOI: 10.7270/Q2XW4JQH |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat)) | BDBM50280934
(1-tert-Butylamino-3-(thiochroman-8-yloxy)-propan-2...)Show InChI InChI=1S/C16H25NO2S/c1-16(2,3)17-10-13(18)11-19-14-8-4-6-12-7-5-9-20-15(12)14/h4,6,8,13,17-18H,5,7,9-11H2,1-3H3 | PDB
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| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Lausanne
Curated by ChEMBL
| Assay Description Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabeled [3H]-8-OH-DPAT ligand displacement |
J Med Chem 39: 126-34 (1996)
Article DOI: 10.1021/jm950410b BindingDB Entry DOI: 10.7270/Q2VX0K7V |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat)) | BDBM50280934
(1-tert-Butylamino-3-(thiochroman-8-yloxy)-propan-2...)Show InChI InChI=1S/C16H25NO2S/c1-16(2,3)17-10-13(18)11-19-14-8-4-6-12-7-5-9-20-15(12)14/h4,6,8,13,17-18H,5,7,9-11H2,1-3H3 | PDB
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| 38 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description The compound was evaluated for binding affinity against 5-hydroxytryptamine 1A receptor in rat hippocampal membranes using [3H]8-OH-DPAT as radioliga... |
Bioorg Med Chem Lett 3: 2035-2038 (1993)
Article DOI: 10.1016/S0960-894X(01)81009-X BindingDB Entry DOI: 10.7270/Q2XW4JQH |
More data for this Ligand-Target Pair | |
Serotonin 1B/1D receptor
(Rattus norvegicus (Rat)) | BDBM50280934
(1-tert-Butylamino-3-(thiochroman-8-yloxy)-propan-2...)Show InChI InChI=1S/C16H25NO2S/c1-16(2,3)17-10-13(18)11-19-14-8-4-6-12-7-5-9-20-15(12)14/h4,6,8,13,17-18H,5,7,9-11H2,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL MCE PC cid PC sid UniChem
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| Article PubMed
| 182 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recherches Servier
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 268: 337-52 (1994)
Article DOI: 10.1016/j.bioorg.2015.06.004 BindingDB Entry DOI: 10.7270/Q2H130HG |
More data for this Ligand-Target Pair | |
HTR2C
(PIG) | BDBM50280934
(1-tert-Butylamino-3-(thiochroman-8-yloxy)-propan-2...)Show InChI InChI=1S/C16H25NO2S/c1-16(2,3)17-10-13(18)11-19-14-8-4-6-12-7-5-9-20-15(12)14/h4,6,8,13,17-18H,5,7,9-11H2,1-3H3 | Reactome pathway
UniProtKB/TrEMBL
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| Article PubMed
| 363 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recherches Servier
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 268: 337-52 (1994)
Article DOI: 10.1016/j.bioorg.2015.06.004 BindingDB Entry DOI: 10.7270/Q2H130HG |
More data for this Ligand-Target Pair | |
Serotonin (5-HT) receptor
(RAT) | BDBM50280934
(1-tert-Butylamino-3-(thiochroman-8-yloxy)-propan-2...)Show InChI InChI=1S/C16H25NO2S/c1-16(2,3)17-10-13(18)11-19-14-8-4-6-12-7-5-9-20-15(12)14/h4,6,8,13,17-18H,5,7,9-11H2,1-3H3 | PDB
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| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recherches Servier
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 268: 337-52 (1994)
Article DOI: 10.1016/j.bioorg.2015.06.004 BindingDB Entry DOI: 10.7270/Q2H130HG |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat)) | BDBM50280934
(1-tert-Butylamino-3-(thiochroman-8-yloxy)-propan-2...)Show InChI InChI=1S/C16H25NO2S/c1-16(2,3)17-10-13(18)11-19-14-8-4-6-12-7-5-9-20-15(12)14/h4,6,8,13,17-18H,5,7,9-11H2,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 1.45E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recherches Servier
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 268: 337-52 (1994)
Article DOI: 10.1016/j.bioorg.2015.06.004 BindingDB Entry DOI: 10.7270/Q2H130HG |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50280934
(1-tert-Butylamino-3-(thiochroman-8-yloxy)-propan-2...)Show InChI InChI=1S/C16H25NO2S/c1-16(2,3)17-10-13(18)11-19-14-8-4-6-12-7-5-9-20-15(12)14/h4,6,8,13,17-18H,5,7,9-11H2,1-3H3 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recherches Servier
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 280: 1241-9 (1997)
BindingDB Entry DOI: 10.7270/Q2CJ8C04 |
More data for this Ligand-Target Pair | |
D(3) dopamine receptor
(Homo sapiens (Human)) | BDBM50280934
(1-tert-Butylamino-3-(thiochroman-8-yloxy)-propan-2...)Show InChI InChI=1S/C16H25NO2S/c1-16(2,3)17-10-13(18)11-19-14-8-4-6-12-7-5-9-20-15(12)14/h4,6,8,13,17-18H,5,7,9-11H2,1-3H3 | PDB
UniProtKB/SwissProt
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CHEMBL MCE PC cid PC sid UniChem
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recherches Servier
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 280: 1241-9 (1997)
BindingDB Entry DOI: 10.7270/Q2CJ8C04 |
More data for this Ligand-Target Pair | |